Description
Generic
Montelukast Sodium
Indications
- Prophylaxis and constant treatment of asthma
- Acute avoidance of Exercise-Induced Bronchoconstriction (EIB)
- Relief of side effects of Unfavorably susceptible Rhinitis (AR): Regular & Lasting Allergic Rhinitis
Pharmacology
Montelukast could be a particular and orally dynamic leukotriene receptor opponent that hinders the cysteinyl leukotriene receptor (CysLT1). The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are items of arachidonic corrosive digestion system and are discharged from different cells, counting pole cells and eosinophils. Cysteinyl leukotrienes and leukotriene receptor occupation have been connected with the pathophysiology of asthma & unfavorably susceptible rhinitis, counting aviation route edema, smooth muscle withdrawal, and changed cellular action related with the fiery handle, which contribute to the signs and side effects of asthma.
Dosage
Dosage
- Asthma & Allergic Rhinitis: 10 mg/day
- Exercise-Induced Bronchoconstriction: 10 mg/day
- Asthma & Unfavorably susceptible Rhinitis: 5 mg/day
- Exercise-Induced Bronchoconstriction: 5 mg/day
- Asthma & Unfavorably susceptible Rhinitis: 4 mg/day
- Exercise-Induced Bronchoconstriction: Not recommended
Patients with both asthma and unfavorably susceptible rhinitis ought to take as it were one measurement day by day in the evening. For the avoidance of Intense avoidance of Exercise-Induced Bronchoconstriction, a single measurement ought to be taken at slightest 2 hours sometime recently work out.
Administration
Interaction
Contraindications
Montelukast is contraindicated in patients who are extremely touchy with any component of this product.
Side Effects
Common: Loose bowels, fever, gastrointestinal distress, cerebral pain, queasiness, heaving, skin responses, upper respiratory tract infection.
Pregnancy & Lactation
There are no satisfactory and well-controlled ponders in pregnant ladies. Montelukast ought to be utilized amid pregnancy as it were on the off chance that clearly required. Montelukast is excreted in the breast drain. So caution ought to be worked out when Montelukast is given to a nursing mother.
Precautions & Warnings
Montelukast isn’t indicated for utilization within the inversion of bronchospasm in intense asthma assaults, counting status asthmatic. Neuropsychiatric occasions counting disturbance, antagonistic vibe, anxiousness, sadness, confusion, unsettling influence in consideration, dream variations from the norm, mental trips, a sleeping disorder, peevishness, memory disability, fretfulness, somnambulism, self-destructive considering and behavior (counting suicide) and tremor.
Therapeutic Class
Leukotriene receptor antagonists
Storage Conditions
Store in cool & dry put underneath 30°C, secure from light & dampness. Keep out of reach of children.
Pharmaceutical Name
Square Pharmaceuticals Ltd.