Indications of Methicol

Mecobalamin is mentioned in-

• Peripheral Neuropathies
• Diabetic Neuropathy
• Vertebral Syndrome
• Nerve Compression Syndrome
• Multiple sclerosis
• Amyotrophic lateral sclerosis
• Parkinson’s disease
• Alzheimer’s disease
• Diabetic retinopathy
• Entrapment neuropathy
• Drug-induced neuropathy
• Megaloblastic anemia due to Vitamin B12 deficiency

Pharmaceutical Name

Square Pharmaceuticals Ltd

Pharmacology

Mecobalamin is the neurologically active form of vitamin B12 and is found in the body as a water-soluble vitamin. It is a cofactor in the enzyme methionine synthase, which transfers methyl groups for methionine regeneration from homocysteine. It boosts erythrocyte production in anemia by increasing nucleic acid synthesis in the bone marrow as well as erythrocyte maturation and division.

Dosage & Administration of Methicol

Tablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of the patient and the severity of the symptoms.

Injection:

• Peripheral neuropathies: The usual adult dosage is 500 mcg of Mecobalamin administered intramuscularly or intravenously three times a week. The dosage should be adjusted according to the age of the patient and the severity of the symptoms.
• Megaloblastic anemia: The usual adult dosage is 500 mcg of Mecobalamin administered intramuscularly or intravenously three times a week. After about two months of the administration, the dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy

Interaction

Neomycin, aminosalicylic acid, H2-blockers, and colchicine all reduced GI tract absorption. Oral contraceptives reduce serum concentrations. Reduced effects of parenteral chloramphenicol on anemia.

Contraindications

Hypersensitivity to any of the ingredients in this product.

Side Effects of Methicol

Mecobalamin is generally well tolerated. However, GI discomfort (including anorexia, nausea, or diarrhea) and rash may occur with Mecobalamin treatment.

Pregnancy & Lactation

It is not advised to use during pregnancy or breastfeeding.

Precautions & Warnings

If there is no reaction after a specific amount of time, the drug should not be administered for months.

Therapeutic Class

Megaloblastic Anemia Treatments.

Storage Conditions

Store at room temperature for oral use. Keep moisture and light at bay.

Store parenteral at room temperature. Avoid exposure to direct sunlight.

Generic Name of Methicol

Mecobalamin