Megenox 100 ML


Megenox 100 ML


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Megestrol Acetate



Megestrol Oral Suspension is used for the treatment of anorexia, cachexia, or unexplained, substantial weight loss in individuals with AIDS or cancer.



A few examiners have detailed on the craving upgrading property of Megestrol Acetic acid derivation and its conceivable utilize in anorexia, cachexia. The exact component by which Megestrol Acetic acid derivation produces impacts in anorexia and cachexia is obscure at the show time but a few considers demonstrate there’s factually critical negative relationship between the level of pro-inflammatory cytokines such as IL1 IL6 ,TNF with different dietary parameters and advancement in quality of life and wieght gain.

Plasma concentrations of Megestrol Acetic acid derivation are subordinate, not as it were on the strategy utilized, but moreover on intestinal and hepatic inactivation of the sedate, which may be influenced by components such as intestinal tract motility, intestinal microbesanti-microbials managed, body weight, count calories, and liver work. The impact of nourishment on the bioavailability of Megestrol Acetic acid derivation Verbal Suspension has not been assessed. The major course of sedate end in human is pee. The cruel end half life extended from 20 to 50 hours in sound subject.


Dosage & Administration

The recommended adult initial dosage of Megestrol Oral Suspension is 800 mg/day (20 ml/day).



When Megestrol Acetate is combined with Zidovudine or Rifabutin, pharmacokinetic investigations demonstrate that there are no substantial changes in pharmacokinetic parameters that would necessitate dosage adjustments. The pharmacokinetics of Megestrol Acetate were not examined with Zidovudine or Rifabutin.



  • History of hypersensitivity to Megestrol Acetate or any component of the formulation
  • Known or suspected pregnancy


Side Effects

Adverse events which occurred in at least 5% of patients in any arm of the two clinical efficacy trials and the open trial are listed below by treatment group. These adverse events should be considered by the physician when prescribing Megestrol Acetate. Those are- diarrhea, impotence, rash, flatulence, hypertension, asthenia, insomnia, nausea, anaemia, fever, libido decreased, dyspepsia, hyperglycemia, headache, vomiting, pneumonia & urinary frequency.

Adverse events which occurred in 1% to 3% of all patients enrolled in the two clinical efficacy trials with at least one follow-up visit during the first 12 weeks of the study are listed below by body system.

  • Abdominal pain, chest pain, infection, candidiasis, and sarcoma are all symptoms of the body as a whole.
  • Cardiovascular System: palpitation and cardiomyopathy
  • Constipation, dry mouth, hepatomegaly, and excessive salivation are symptoms of the digestive system.
  • Leukopenia affects the hemic and lymphatic systems.
  • Metabolic and Nutritional: LDH increased, oedema and peripheral oedema
  • Nervous System: paresthesia, confusion, convulsion, depression, neuropathy, hypesthesia and abnormal thinking
  • Respiratory System: dyspnea, cough and lung disorder
  • Skin and Appendages: alopecia, herpes, pruritus, vesiculobullous rash, sweating and skin disorder
  • Urogenital System: albuminuria, urinary incontinence, urinary tract infection and gynecomastia


Pregnancy & Lactation

X is the pregnancy category. In pregnant women, there are no sufficient and well-controlled trials. If this drug is used during pregnancy or if the patient becomes pregnant while taking it, the fetus should be informed. Women of childbearing age should be counseled against getting pregnant. If Megestrol Acetate is required, nursing should be stopped due to the risk of harmful effects on the newborn.


Precautions & Warnings

General weight reduction therapy with Megestrol Acetate should be started only when treatable causes of weight loss have been identified and treated. Possible cancers, systemic infections, gastrointestinal issues affecting absorption, endocrine disease, and renal or mental ailments are among the treatable reasons. The effects of the drug on HIV viral replication are yet to be determined. In patients with a history of thromboembolic illness, use with caution. Diabetics’ Use: The usage of Megestrol Acetate has been linked to an increase in insulin needs and an exacerbation of pre-existing diabetes.


Therapeutic Class

Hormonal Chemotherapy


Storage Conditions


Store at 20° to 25°C. Protect from heat. Shake well immediately before use.


Pharmaceutical Name

ACME Laboratories Ltd.