Generic

Indications

Mecobalamin is used to treat a variety of ailments.

• Neuropathies of the Periphery
• Diabetic Neuropathy is a kind of neuropathy caused by diabetes.
• Verteberal Syndrome is a condition that affects animals.
• Nerve Compression Syndrome is a condition when the nerves are compressed.
• Multiple sclerosis (MS) is a disease that affects people
• Amyotrophic lateral sclerosis (ALS) is a kind of amyotrophic lateral
• Parkinson’s disease is a neurological disorder that affects people.
• Alzheimer’s disease is an illness that affects people of all
• Diabetic retinopathy is a kind of retinopathy caused by diabetes.
• Neuropathy caused by entrapment
• Neuropathy caused by drugs
• Vitamin B12 deficiency causes megaloblastic anemia.

Pharmacology

Mecobalamin is the neurologically active form of vitamin B12, which is found in the body as a water-soluble vitamin. It’s a cofactor in the enzyme methionine synthase, which helps methionine regenerate from homocysteine by transferring methyl groups. It boosts erythrocyte production in anemia by increasing nucleic acid synthesis in the bone marrow as well as erythrocyte maturation and division.

Dosage & Administration

Tablet: The usual adult dosage is 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.

Injection:

• Peripheral neuropathies: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
• Megaloblastic anemia: The usual adult dosage is  500 mcg Mecobalamin administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy

Interaction

Neomycin, aminosalicylic acid, H2-blockers, and colchicine all reduced GI tract absorption. Oral contraceptives lower serum concentrations. Parenteral chloramphenicol has less of an effect on anemia.

Contraindications

Hypersensitivity to any of the product’s ingredients.

Side Effects

Mecobalamin is generally well tolerated. However, following the administration of Mecobalamin, some side effects such as GI discomfort (including anorexia, nausea, or diarrhea) and rash may occur.

Pregnancy & Lactation

Precautions & Warnings

If there is no reaction to the drug after a specific amount of time, it should not be taken for months.

Therapeutic Class

Storage Conditions

Store at room temperature if used orally. Moisture and light should be avoided.
Store at room temperature if using as a parenteral. Direct sunlight should be avoided.

Pharmaceutical Name

ACME Laboratories Ltd.