Indications of Maxima 20 Capsule

• Esomeprazole is prescribed to treat chronic heartburn and other GERD symptoms.
• In order to treat erosive esophagitis,
• For the maintenance of erosive esophagitis healing
• In patients with duodenal ulcer illness, in conjunction with amoxicillin and clarithromycin, for the elimination of Helicobacter pylori infection.
• Syndrome of Zollinger-Ellison
• Dyspepsia caused by acid
• Ulcers of the duodenum and stomach.

Pharmacology of Maxima 20 Capsule

Esomeprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase in the gastric parietal cell, suppressing gastric acid output. The first single optical isomer of a proton pump inhibitor, esomeprazole (S-isomer of omeprazole), provides superior acid control than racemic proton pump inhibitors.

Assimilation: Esomeprazole capsules contain an enteric-coated pellet detailing of esomeprazole magnesium. After verbal organization crest plasma levels (Cmax) happen at around 1.5 hours (Tmax). The Cmax increments relatively when the dosage is expanded, and there’s a three-fold increment within the region beneath the plasma concentration-time bend (AUC) from 20 to 40 mg. At rehashed once day by day dosing, the systemic bioavailability is around 90% compared to 64% after a single measurements. The AUC after organization of a single dosage of esomeprazole is diminished by 33-53% after nourishment admissions compared to fasting conditions. Esomeprazole ought to be taken at slightest one hour some time recently suppers.

Esomeprazole binds to plasma proteins 97 percent of the time. Over a concentration range of 2 20 mmol/L, plasma protein binding remains constant. In healthy volunteers, the apparent volume of distribution at steady state is around 16 L.

Esomeprazole is extensively processed by the cytochrome P450 (CYP) enzyme system in the liver. Esomeprazole’s metabolites have no anti-secretory properties. The CYP2C19 isoenzyme, which creates the hydroxy and desmethyl metabolites, is responsible for the majority of esomeprazole metabolism. The sulphone metabolite is formed by CYP3A4, which is responsible for the remaining proportion.

Dosage & Administration of Maxima 20 Capsule

Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks. The majority of patients are healed within 4 to 8 weeks. For patients who don’t heal after 4-8 weeks, an additional 4-8 weeks of treatment may be considered. Maintenance of Healing of Erosive

Esophagitis: 20 mg Once Daily (Clinical studies did not extend 6 months).

Symptomatic GERD: 20 mg Once Daily for 4 Weeks. If symptoms do not resolve completely after 4 weeks, an additional 4 weeks of treatment may be considered.

Helicobacter Pylori eradication: Triple Therapy to reduce the risk of Duodenal Ulcer recurrence-Esomeprazole 40 mg Once Daily for 10 days, Amoxicillin 1000 mg Twice Daily for 10 days, Clarithromycin 500 mg Twice Daily for 10 days.

Zollinger-Ellison Syndrome: The dose is 20-80 mg once daily. The dosage should be adjusted individually and treatment continued as long as clinically indicated.

Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks according to the response.

Duodenal ulcer: 20 mg once daily for 2-4 weeks. Gastric ulcer: 20-40 mg once daily for 4-8 weeks.

Injection: The recommended adult dose is 40 mg Esomeprazole given once daily by intravenous injection (not less than 3 minutes) or intravenous infusion (10 to 30 minutes). Esomeprazole IV injection should not be administered concomitantly with any other medications through the same intravenous site. Treatment with Esomeprazole IV injection should be discontinued as soon as the patient is able to resume treatment with Esomeprazole delayed-release capsules. Safety and effectiveness in paediatric patients have not been established.

Interaction of Maxima 20 Capsule

CYP2C19 and CYP3A4 substantially metabolize esomeprazole in the liver. Esomeprazole does not appear to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, or 3A4 in vitro or in vivo investigations. There should be no clinically significant interactions with medicines processed by these CYP enzymes. Esomeprazole has no clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin, according to drug interaction studies.

Esomeprazole may possibly meddled with CYP2C19, the major Esomeprazole metabolizing chemical. Co-administration of Esomeprazole 30 mg and diazepam, a CYP2C19 substrate has brought about in a 45% diminish in clearance of diazepam. Expanded plasma levels of diazepam have been watched 12 hours after dosing and onwards. Esomeprazole hinders gastric corrosive emission. In this manner, Esomeprazole may meddled with the retention of drugs where gastric pH is an vital determinant of bioavailability (e.g., ketoconazole, press salts and digoxin).

Contraindications

In patients who have a history of hypersensitivity to any of the formulations, esomeprazole is not recommended.

Side Effects of Maxima 20 Capsule

Headache, diarrhoea, nausea, flatulence, abdominal pain, constipation, and dry mouth are the most common side effects reported with Esomeprazole. When compared to short-term treatment, there is no difference in the categories of linked adverse events noticed with maintenance treatment up to 12 months.

Pregnancy & Lactation

In pregnant women, there are no sufficient and well-controlled trials. No teratogenic effects have been found in animal investigations. Esomeprazole excretion in milk has not been studied. If the use of esomeprazole is thought necessary, breastfeeding should be terminated.

Precautions & Warnings

General: A symptomatic response to esomeprazole medication does not rule out the possibility of gastric cancer.

Esomeprazole pills should be taken at least one hour before meals, according to the manufacturer’s instructions. One tablespoon of applesauce can be put to an empty bowl for patients who have trouble swallowing capsules, and the Esomeprazole capsules can be opened and the pellets carefully spilled into the applesauce. The pellets should be combined with applesauce and quickly eaten. The applesauce should not be too hot, and it should be mushy enough to consume without chewing. Chewing or crushing the pellets is not recommended.

Therapeutic Class

Inhibitor of the proton pump.

Storage Conditions

Store in a dry area at a temperature of not more than 30°C. Light and dampness should be avoided. Keep out of children’s reach.

Pharmaceutical Name of Maxima 20 Capsule

ACME Laboratories Ltd

Generic of Maxima 20 Capsule

Esomeprazole Magnesium Trihydrate