Generic

Loteprednol Etabonate

Indications

For post-operative inflammation and pain, Loteprednol Gel is suggested. Additionally, it has been shown to be beneficial in treating illnesses such as allergic conjunctivitis, rosacea keratitis, superficial punctate keratitis, herpes zoster corneatitis, iritis and cyclitis that are steroid responsive.

Pharmacology

We believe loteprednol works by inducing phospholipase A2 inhibitory proteins, which restrict the creation of powerful mediators of inflammation such as prostaglandin and leukotriene by blocking the release of arachidonic acid, which is their common precursor.

Dosage & Administration

Shake the bottle vigorously before using

Steroid responsive disease treatment: Apply 1 to 2 drops of Loteprednol into the conjunctival sac of the affected eye(s) four times daily. During the initial treatment within the first week, the dosing may be increased, up to 1 drop every hour, if necessary. Care should be taken not to discontinue therapy prematurely.

Post-Operative Inflammation: Apply 1 to 2 drops of Loteprednol into the conjunctival sac of the operated eye(s) four times daily beginning 24 hours after surgery and continuing throughout the first 2 weeks of the post-operative period.

Contraindications

All conjunctivitis, cornea, and viral illnesses are contraindicated. People with known or suspected hypersensitivity to any of the components in this preparation or to other corticosteroids should not take this medication.

Side Effects

cataract development; subsequent infection of the ocular surface following inhibition of the host response.

Pregnancy & Lactation

If you are pregnant, you should not use this product. Loteprednol Etabonate does not appear to transfer into breast milk.

Precautions & Warnings

• For ophthalmic use only.
• If this product is used for 10 days or longer, intraocular pressure should be monitored.
• Fungal infections of the cornea are particularly prone to develop coincidentally with long-term use of steroid topically.
• Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve, defects in visual acuity and visual field, and in posterior subcapsular cataract formation.
• Use of a corticosteroid medication in the treatment of patients with a history of herpes simplex requires great caution.

Therapeutic Class

Ophthalmic Steroid preparations

Storage Conditions

Pharmaceutical Name

General Pharmaceuticals Ltd.