Generic

Losartan Potassium

Indications

Hypertension: Losartan Potassium is demonstrated for the treatment of hypertension. It may be utilized alone or in combination with other antihypertensive operators (eg. thiazide diuretics).

Pharmacology

Losartan Potassium is the primary non-peptide orally dynamic angiotensin II receptor blocker. It ties to the AT1 receptor found in numerous tissues (e.g. vascular smooth muscle, adrenal organ, kidneys and the heart) and diminishes a few vital natural activities counting vasoconstriction and the discharge of aldosterone mindful for hypertension.

Dosage & Administration

The normal beginning and upkeep measurements is 50 mg once day by day for most patients. In the event that the antihypertensive impact utilizing 50 mg once every day is insufficient, 25 mg twice every day is prescribed earlier to expanding the measurements. For patients with intravascular volume-depletion (e.g., those treated with high-dose diuretics), a beginning measurements of 25 mg once every day ought to be considered. Losartan Potassium can be managed once or twice day by day. The overall day by day measurements ranges from 25 mg to 100 mg.

Interaction

Rifampicin and fluconazole decrease levels of dynamic metabolite of Losartan Potassium. Concomitant utilize of Losartan Potassium and hydrochlorothiazide may lead to potentiation of the antihypertensive impacts. Concomitant utilize of potassium-sparing diuretics (eg, spironolactone, triamterene, amiloride), potassium supplements or salt substitutes containing potassium may lead to increments in serum potassium. The antihypertensive impact of losartan may be constricted by the non-steroidal anti-inflammatory sedate indomethacin. The utilize of ACE-inhibitor, angiotensin receptor opponent, an anti-inflammatory sedate and a thiazide diuretic at the same time increments the hazard of renal disability.

Contraindications

Losartan Potassium is contraindicated in pregnant ladies and in patients who are extremely touchy to any component of this item. Losartan Potassium ought to not be managed with Aliskiren in patients with diabetes.

Side Effects

The side impacts with the utilize of Losartan Potassium are mellow and temporal in nature. The foremost common side impacts are discombobulation, the runs, nasal clog, hack, upper respiratory contamination. Other side impacts are weariness, oedema, stomach torment, chest torment, queasiness, migraine & pharyngitis.

Pregnancy & Lactation

Pregnancy Category D. The hazard to the baby increments on the off chance that Losartan Potassium is managed amid the moment or third trimesters of pregnancy. It isn’t known whether Losartan Potassium is excreted in human drain, as numerous drugs are excreted in human milk as a result of the potential for unfavorable impacts on the nursing newborn child, a decision should be made whether to suspend nursing or suspend the medicate, taking into consideration the significance of the medicate to the mother.

Precautions & Warnings

Utilize of Losartan Potassium amid the moment and third trimesters of pregnancy decreases fetal renal work and increments fetal and neonatal horribleness and passing. In patients who are intravascularly volume-depleted (e.g., those treated with high-dose diuretics), symptomatic hypotension may happen. Plasma concentration of Losartan Potassium is essentially expanded in cirrhotic patients. Changes in renal work counting renal disappointment have been detailed in renal impeded persistent.

Therapeutic Class

Angiotensin-ll receptor blocker

Storage Conditions

keep in a dry place absent from light and warm. Keep out of the reach of children.

Pharmaceutical Name

Drug International Ltd.