Lomeflox 5ML

106412107900201

Lomeflox 5ML

70.00৳ 

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In Stock

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Description

Generic

Lomefloxacin

 

Indications

Lomefloxacin ophthalmic preparation is used to treat bacterial infections such as conjunctivitis, blepharitis, and blepharoconjunctivitis caused by Lomefloxacin-susceptible germs, as well as corneal ulcers caused by Staphylococcus aureus.

 

Pharmacology

Lomefloxacin is a difluoroquinolone derivative and a bacterial gyrase inhibitor, effective against gram-positive and gram-negative bacteria. Lomefloxacin has low acute toxicity after systemic and topical ophthalmic application. Lomefloxacin interferes with bacterial DNA-related processes, such as the initiation, extension, and termination stages of DNA replication, transcription, DNA repair, recombination, rearrangement, supercoiling, and relaxation. The target molecule of quinolones is the bacterial gyrase A subunit (topoisomerase II). The formation of a stable complex between the quinolone and the entire A2B2 gyrase trimer will cause the enzyme function to be impaired, leading to the rapid destruction of sensitive bacteria.

Cross-resistance only reported cross-resistance with other quinolones, but did not report cross-resistance with any other group of antibiotics. There are no clinical studies on the efficacy of cases of chlamydia infection.

 

Dosage & Administration

Adults and children (above 1 year of age): Instill 2-3 times daily 1 drop into the lower conjunctival sac. At the beginning of the treatment application should be more frequent, apply 5 drops within 20 minutes or 1 drop every hour during 6-10 hours. Duration of the treatment: 7 to 9 days.

May be taken with or without food.

 

Interaction

No ophthalmic medicines containing heavy metals, such as zinc, should be used for 15 minutes before and after the application of Lomefloxacin to avoid a decline in efficacy. Lomefloxacin eye drops should not be used with bacteriostatic ophthalmic medicines.

 

Contraindications

Hypersensitivity to quinolones, excipients, or the active component. Antibiotic treatment for a long time may promote the development of secondary fungal infections or boost the growth of bacteria that aren’t susceptible.

 

Side Effects

In 4.7 percent of users, minor and transitory burning occurred shortly after instillation of the eye drops. Although there hasn’t been any reports of phototoxicity following ophthalmic usage, photosensitization is a possibility. Because allergic symptoms such as asthma, dyspnea, urticaria, erythema, pruritus, and hypersensitization have been documented after systemic use of Lomefloxacin, they cannot be ruled out after topical ophthalmic usage.

 

Pregnancy & Lactation

Lomefloxacin penetrates the placenta barrier and is excreted into the maternal milk following a systemic dose of 20 mg/kg in rats. There are no clinical studies on the use of Lomefloxacin eye drops in humans during pregnancy or lactation. As a result, the medicine should only be administered when the potential benefit surpasses the danger to the fetus or newborn.

 

Precautions & Warnings

After systemic but not topical ophthalmic usage of Lomefloxacin, some isolated occurrences of phototoxicity have been observed. Nonetheless, excessive exposure to sunlight or UV-radiation should be avoided when taking Lomefloxacin.

 

Therapeutic Class

Ophthalmic antibacterial medicines, 4-quinolone preparations

 

Storage Conditions

Store at 15-25° C

 

Pharmaceutical Name

Aristopharma Ltd.