Indications

Atorvastatin is demonstrated as an aide to count calories to diminish hoisted add up to cholesterol, LDL cholesterol, apolipoprotein B (Apo-B), and triglycerides levels in taking after infections when the reaction to count calories and other non-pharmacological measures are inadequate. To diminish add up to cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolemia. To diminish hoisted cholesterol and triglycerides in understanding with blended dyslipidemia (Fredrickson Sort Ia and Ib). For the treatment of patients with lifted serum triglyceride levels in hypertriglyceridemia (Fredrickson Sort IV). For the treatment of patients with dysbetalipoproteinemia (Fredrickson Sort III).To decrease cardiac ischaemic occasions in patients with asymptomatic or gentle to direct symptomatic coronary supply route malady with hoisted LDL-cholesterol level. To diminish add up to and LDL-cholesterol concentrations in patients with hypercholesterolemia related with or exacerbated by diabetes mellitus or renal transplantation.

Pharmacology

Atorvastatin could be a specific inhibitor of HMG-CoA reductase. This chemical is the rate-limiting protein dependable for the transformation of HMG-CoA to mevalonate, an antecedent of sterols, counting cholesterol. Atorvastatin brings down plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol amalgamation within the liver and increments the number of hepatic LDL receptors on the cell surface for improved take-up and catabolism of LDL.

Dosage & Administration

Primary hypercholesterolemia and combined hyperlipidemia-

Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to the max. 80 mg once daily.

Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to the usual max. 20 mg once daily.

Familial hypercholesterolemia-

Adults: Initially 10 mg daily, increased at intervals of at least 4 weeks to 40 mg once daily; if necessary, further increased to max. 80 mg once daily (or 40 mg once daily combined with anion-exchange resin in heterozygous familial hypercholesterolemia).

Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to the usual max. 80 mg once daily.

Prevention of cardiovascular events-

Adults: Initially 10 mg once daily adjusted according to the response.

Interaction

Concurrent use of cyclosporin, fibre acid derivatives, erythromycin, azole antifungals, and niacin increases the risk of myopathy while taking Atorvastatin. When Atorvastatin was used with antihypertensives or hypoglycemic medications, no clinically meaningful interactions were seen. If Atorvastatin is used with digoxin, erythromycin, oral contraceptives, colestipol, antacid, or warfarin, patients should be continuously watched.

Contraindications

Patients who are hypersensitive to any component of Locol 10 should avoid taking it. Active liver disease or unexplained chronic transaminase increases are contraindicated with Locol 10. It’s also not recommended for patients who have had a significant reaction to HMG-CoA reductase inhibitors in the past.

Side Effects

Locol 10 is well tolerated by most people. Constipation, flatulence, dyspepsia, and abdominal pain are the most common Atorvastatin side effects. Infection, headache, back pain, rash, asthenia, arthralgia, and myalgia are some of the other side effects.

Pregnancy & Lactation

Pregnancy: Locol 10 is contraindicated amid pregnancy. Security in pregnant ladies has not been built up. No controlled clinical trials with Locol 10 have been conducted in pregnant ladies. Uncommon reports of intrinsic inconsistencies taken after the intrauterine presentation to HMG-CoA reductase inhibitors have been gotten. The creature thinks about having appeared poisonous quality to generation. Maternal treatment with atorvastatin may decrease the fetal levels of mevalonate which may be a forerunner of cholesterol biosynthesis. Locol 10 ought to not be used in ladies who are pregnant, attempting to get to be pregnant, or suspect they are pregnant. Treatment with atorvastatin ought to be suspended for the length of pregnancy or until it has been decided that the lady isn’t pregnant

Lactation: It is not known whether Locol 10 or its metabolites are excreted in human milk. In rats, plasma concentrations of atorvastatin and its active metabolites are similar to those in milk. Because of the potential for serious adverse reactions, women taking atorvastatin should not breastfeed their infants. Atorvastatin is contraindicated during breastfeeding.

Precautions & Warnings

Effects on the liver: Liver function tests should be done before starting treatment and then on a regular basis after that. In patients who drink a lot of alcohol or have a history of liver illness, atorvastatin should be administered with caution. If severely raised CPK levels or myopathy is diagnosed or suspected, Locol 10 medication should be stopped.

Therapeutic Class

Statins and other anti-anginal and anti-ischemic medications.

Storage Conditions

Keep away from light and heat in a dry location. Keep out of children’s reach.

Generic

Atorvastatin Calcium

Pharmaceutical Name

Popular Pharmaceuticals Ltd