Indications of Lipostat 10

When the response to diet and other non-pharmaceutical measures is insufficient, atorvastatin can be used as a dietary adjuvant to reduce elevated total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B (ApoB), and glycerol in the following diseases: Trimester level.

Reduces total cholesterol and low-density lipoprotein cholesterol in patients with heterozygous and homozygous familial hypercholesterolemia.
Reduces high cholesterol and triglycerides in patients with mixed dyslipidemia (Fredrickson type Ia and Ib). is used to treat patients with elevated serum triglyceride levels in hypertriglyceridemia (Fredrickson type IV). is used to treat patients with abnormal beta lipoproteinemia (Fredrickson type III).
Reduces cardiac ischemia events in patients with mild to moderate symptomatic or asymptomatic coronary artery disease with elevated LDL cholesterol levels.

Reduce total cholesterol and LDL cholesterol levels in patients with hypercholesterolemia associated with or exacerbated by diabetes or kidney transplantation.

Pharmacology of Lipostat 10

Atorvastatin is a selective HMG-CoA reductase inhibitor. This enzyme is the limiting enzyme responsible for converting HMGCoA to mevalonate, which is the precursor to sterols (including cholesterol). Atorvastatin reduces plasma levels of cholesterol and lipoproteins by inhibiting HMGCoA reductase and cholesterol synthesis in the liver and increases the number of hepatic LDL receptors on the cell surface to enhance absorption and catabolism of LDL.

Dosage & Administration

Primary hypercholesterolemia and combined hyperlipidemia
adults: usually 10 mg daily; if necessary, it can be increased to at least every 4 weeks. 80 mg once a day.
children (10 to 18 years): Initially 10 mg per day, increasing to the usual maximum dose every at least 4 weeks if necessary. 20 mg once a day.

Familial hypercholesterolemia
Adults: Initially 10 mg per day, increasing to 40 mg per day every at least 4 weeks; if necessary, increase further to the maximum. 80 mg once daily (or 40 mg once daily in combination with anion exchange resin in heterozygous familial hypercholesterolemia).
children (10 to 18 years): Initially 10 mg per day, increasing to the usual maximum dose every at least 4 weeks if necessary. 80 mg once a day.
Prevention of cardiovascular events

Adults: Initially 10 mg per day, adjusted for a response.

Interactions of Lipostat 10

The risk of myopathy during treatment with atorvastatin increases with simultaneous administration of cyclosporine, fibric acid derivatives, erythromycin, azole antifungals, and niacin. When atorvastatin was used in combination with antihypertensive or hypoglycemic drugs, no clinically significant interactions were observed. If atorvastatin is added to digoxin, erythromycin, oral contraceptives, colestipol, antacids, and warfarin, the patient should be closely monitored.

Contraindications

Lipostat 10 should not be used in patients who are allergic to any component of the drug. Lipostat 10 is contraindicated for active liver disease or continuous and unexplained increase in serum transaminase. It is also contraindicated in patients with a history of serious adverse reactions to the previous use of HMGCoA reductase inhibitors.

Side Effects of Lipostat 10

Lipostat 10 is usually well tolerated. The most common side effects of atorvastatin are constipation, flatulence, indigestion, and abdominal pain. Other side effects include infection, headache, back pain, skin rash, weakness, joint pain, and myalgia.

Pregnancy

Pregnancy:Lipostat 10 is contraindicated during pregnancy. The safety of pregnant women has not been determined. No controlled clinical trials of atorvastatin have been conducted in pregnant women. Rare reports of birth defects have been received after intrauterine exposure to HMG-CoA reductase inhibitors. Animal studies have shown that it is toxic to reproduction. Treatment of mothers with atorvastatin may reduce the level of mevalonate in the fetus, which is a precursor of cholesterol biosynthesis. Lipostat 10 should not be used in women who are pregnant, trying to become pregnant, or are suspected of becoming pregnant. Atorvastatin treatment should be stopped during pregnancy or before it is determined that the woman is not pregnant.
Lactation period: It is unknown whether atorvastatin or its metabolites are excreted from human milk. In rats, the plasma concentrations of atorvastatin and its active metabolite are similar to those in milk. Due to the possibility of serious adverse reactions, women taking atorvastatin should not breastfeed their babies. Lipostat 10 is contraindicated during lactation.

Precautions

Liver effect: liver function tests should be performed regularly before and after treatment. Patients who drink a lot of alcohol or have a history of liver disease should use atorvastatin with caution. If there is a significant increase in CPK levels or myopathy is diagnosed or suspected, treatment with atorvastatin should be discontinued.

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs, Statins

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Pharmaceutical Name of Lipostat 10

Navana Pharmaceuticals Ltd

Generic of Lipostat 10

Atorvastatin Calcium