Description
Indications of Lincocin 300 Capsule
Clindamycin has been appeared to be viable within the treatment of the taking after contaminations when caused by helpless anaerobic microbes or helpless strains of gram positive microscopic organisms such as Streptococci, Staphylococci and Pneumococci; Upper respiratory contaminations, Lower respiratory contaminations, Skin and delicate tissue contaminations, Bone and joint contaminations, Pelvic contaminations, Intra-abdominal diseases, Septicemia and endocarditis, Dental contaminations. As an elective treatment when utilized in combination with quinine or amodiaquine for the treatment of multi-drug safe Plasmodium falciporum disease.
Pharmacology of Lincocin 300 Capsule
Gliclazide is a sulfonylurea of the second generation with hypoglycemic and perhaps hematological effects. It increases insulin release from pancreatic -cells and lowers hepatic glucose output by boosting Ca+2 transport across the -cell membranes.
Dosage & Administration of Lincocin 300 Capsule
Dosage of Clindamycin Capsule:
- Serious Infections: 150 mg-300 mg every six hours.
- More severe infections: 300 mg-450 mg every six hours.
To avoid the possibility of oesophageal irritation, Clindacin capsules should be taken with a full glass of water.
Several researches has found that Clindamycin 300 mg capsule provides plasma concentration over MIC90 for more than 12 hours. This finding supports the twice-daily dosing of Clindacin 300 mg capsule, particularly in SSTIs & RTIs. However, in case of bone & joint infections, diabetic foot infections dose of Clindamycin should be 300 mg capsule 3-4 times daily.
Dosage of Clindamycin Powder for oral solution:
- Serious infections: 8-12 mg/kg/day divided into 3 or 4 equal doses.
- Severe infections: 13-16 mg/kg/day divided into 3 or 4 equal doses.
- More severe infections: 17-25 mg/kg/day divided into 3 or 4 equal doses.
In pediatric patients weighing 10 kg or less, 1/2 teaspoon (37.5 mg) three times a day should be considered the minimum recommended dose.
Dosage of Clindamycin IV/IM Injection:
Adults-
- Serious infections due to aerobic gram-positive cocci and the more susceptible anaerobes: 600-1200 mg/day in 2- 4 equal doses.
- More severe infections: 1200-2700 mg/day in 2-4 equal doses.
- For more serious infections: these doses may have to be increased. In life-threatening situations due to either aerobes or anaerobes, these doses may be increased.
- Doses of as much as 4800 mg daily have been given intravenously to adults. Single intramuscular injections of greater than 600 mg are not recommended.
Neonates (less than 1 month): 15 to 20 mg/kg/day in 3 to 4 equal doses. The lower effective dosage may be adequate for small prematures.
Pediatric patients (1 month of age to 16 years):
- 20 to 40 mg/kg/day in 3 or 4 equal doses. The higher doses would be used for more severe infections.
- Parenteral therapy may be changed to Capsules (clindamycin hydrochloride) when the condition warrants and at the discretion of the physician.
- In cases of (3-hemolytic streptococcal infections, treatment should be continued for at least 10 days.
Interaction of Lincocin 300 Capsule
Clindamycin improves the activity of other neuromuscular blocking specialists. Subsequently, it ought to be utilized with caution in patients getting such specialists. Hostility has been illustrated between clindamycin and erythromycin in vitro. Since of conceivable clinical importance, these two drugs ought to not be managed concurrently.
Contraindications
- Clindamycin is contraindicated in patients previously found to be sensitive to clindamycin or any of the ingredients of this medicine.
Side Effects of Lincocin 300 Capsule
The adverse effects have been reported with the use of clindamycin are- abdominal pain, oesophagitis and oesophagial ulcer, nausea, vomiting and diarrhoea, pruritus, skin rashes, urticaria.
Pregnancy & Lactation
Pregnancy Category B. Clindamycin crosses the placenta in people. After different dosages, amniotic liquid concentrations were roughly 30% of maternal concentrations. Clindamycin ought to be utilized in pregnancy as it were in the event that clearly required. Clindamycin has been detailed to seem in breast milk. Subsequently, it isn’t prescribed for nursing moms on the off chance that not clearly required.
Precautions & Warnings
Clindamycin should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.
Therapeutic Class
Macrolides
Storage Conditions
Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children’s reach.
Pharmaceutical Name of Lincocin 300 Capsule
ACME Laboratories Ltd
