Description
Indications of Leptic 2 Tablet
It is suitable for the treatment of panic disorder with or without agoraphobia. Panic disorder is characterized by unexpected panic attacks and related concerns about recurrence, concerns about the effects or consequences of the attack.
It can also be used alone or as an adjuvant treatment for Lennox-Gastaut syndrome (minor variant), dyskinesias and myoclonic seizures. It may be suitable for patients with absence seizures (minor illnesses) who do not respond to succinimide.
The efficacy of long-term use of clonazepam, that is, more than 9 weeks, has not been systematically studied in controlled clinical trials. Clinicians who choose to use clonazepam for a prolonged period should periodically re-evaluate the long-term effectiveness of the drug for individual patients.
Pharmacology of Leptic 2 Tablet
Clonazepam exhibits pharmacological properties shared by benzodiazepines, including anticonvulsant, sedative, muscle relaxation, and anxiolytic effects. The central effects of benzodiazepines are mediated by enhancement of GABAergic neurotransmission at inhibitory synapses. In the presence of benzodiazepines, the affinity of GABA receptors for neurotransmitters is enhanced through positive allosteric regulation, resulting in an increase in the effect of released GABA on post-synaptic transmembrane chloride flux.
There is also data in animals showing the effect of clonazepam on serotonin. Animal data and human EEG studies have shown that clonazepam can rapidly inhibit many types of paroxysmal activities, including spike and wave (small) discharges during absences, slow spikes, whole-body spikes, and time or spikes at other locations. and jagged peaks and waves. Generalized EEG abnormalities are more often suppressed than focal abnormalities. Based on these findings, clonazepam has a beneficial effect on generalized and focal epilepsy.
Dosage and Administration of Leptic 2 Tablet
- Adults: The beginning measurements for grown-ups with seizure clutters ought to not surpass 1.5 mg/day isolated into three dosages. Measurement may be expanded in increases of 0.5 to 1 mg each 3 days until seizures are enough controlled or until side impacts block any encourage increment. Support measurement must be individualized for each quiet depending upon reaction. Greatest prescribed every day measurements is 20 mg.
- The starting dosage for grown-ups with freeze clutter is 0.25 mg given in two partitioned dosage. An increment to the target measurements for most patients of 1 mg/day may be made after 3 days.
- Pediatric Patients: In arrange to play down tiredness, the introductory dosage for newborn children and children (up to 10 a long time of age or 30 kg of body weight) ought to be between 0.01 and 0.03 mg/kg/day but not to surpass 0.05 mg/kg/day given in two or three partitioned measurements.
- Infants and children: half of a vial (0.5 mg) by moderate IV infusion or by IV infusion.
- Adults: 1 vial (1 mg) by moderate IV infusion or by IV implantation. This measurements can be rehashed as required (1-4 mg are as a rule adequate to invert the status). In adults, the rate of infusion must not surpass 0.25 – 0.5 mg per diminutive (0.5-1.0 ml of the arranged arrangement) and a add up to dosage of 10 mg ought to not be surpassed.
Interaction of Leptic 2 Tablet
Clonazepam does not show up to modify the pharmacokinetics of phenytoin, carbamazepine or phenobarbital. The impact of Clonazepam on the digestion system of other drugs has not been explored.
Contraindications
Side Effects of Leptic 2 Tablet
The most habitually happening side impacts of Clonazepam are referable to CNS sadness. Encounter in treatment of seizures has appeared that tiredness has happened in roughly 50% of patients and ataxia in around 30%. In a few cases, these may decrease with time; behavior issues have been famous in around 25% of patients. Irregular eye developments, aphonia, coma, tremor, vertigo, disarray, misery, amnesia, visualizations, mania, expanded charisma, a sleeping disorder, psychosis & palpitations may too happen.
Pregnancy & Lactation
Pregnancy: From preclinical ponders it cannot be avoided that clonazepam has the plausibility of creating innate distortions. From epidemiological assessments there’s prove that anticonvulsant drugs act as teratogens. In any case, it is troublesome to decide from distributed epidemiological reports which sedate or combination of drugs is responsible for absconds within the infant. The plausibility too exists that other variables e.g. hereditary components or the epileptic condition itself may be more critical than medicate treatment in driving to birth absconds. Beneath these circumstances, the sedate ought to as it were be managed to pregnant ladies in the event that the potential benefits exceed the chance to the embryo. Amid pregnancy, Clonazepam may be managed as it were in case there’s a compelling sign. Organization of tall measurements within the final trimester of pregnancy or amid work can cause abnormalities within the pulse of the unborn child and hypothermia, hypotonia, mellow respirato
Nursing Moms: In spite of the fact that the dynamic fixing of Clonazepam has been found to pass into the maternal drain in little sums as it were, moms experiencing treatment with this sedate ought to not breastfeed. In the event that there’s a compelling sign for Clonazepam, breastfeeding ought to be ceased.
Precautions & Warnings
When used in patients with several different types of epilepsy, clonazepam may increase or contribute to the occurrence of generalized tonic-clonic seizures. This may require adding appropriate anticonvulsants or increasing their doses. Simultaneous use of valproic acid and clonazepam can produce a missing state.
Therapeutic Class
Adjunct anti-epileptic drugs, Benzodiazepine hypnotics
Storage Conditions
Keep in a dry put absent from light and warm. Keep out of the reach of children.
Pharmaceutical Name of Leptic 2 Tablet
ACME Laboratories Ltd
Generic of Leptic 2 Tablet
Clonazepam
