Generic

Ispaghula Husk

Indications

Ispaghula husk is used as a bulking agent in this medication. This implies that when eaten with water, it expands the feces (stools) and aids the passage of solid waste through the body. Ispaghula Husk sachets are used to treat constipation and other situations where soft stools are preferable. They’re also utilized for people who need to eat a lot of fiber.

Pharmacology

The majority of the Ispaghula reaches the caecum intact and strongly polymerized after four hours of eating. Ispaghula husk increases the amount of moisture in the stool, as well as the weight of wet and dry stool, and reduces gastrointestinal transit time. In the gut, anaerobic fermentation of soluble non-starch polysaccharides from Ispaghula seed produces short chain fatty acids, acetate, propionate, and butyrate. Colonocytes prefer butyric acid as an oxidative substrate, which might be beneficial in the treatment of ulcerative colitis. Ispaghula also lowers cholesterol levels. Ispaghula is thought to enhance cholesterol alpha hydroxylase activity, HMG-CoA reductase activity, and fractional turnover of both chenodeoxycholic and cholic acids. As a result, cholesterol absorption is reduced, and LDL cholesterol is reduced.

Dosage

Constipation:

• Adult: 3.5 g 1-3 times daily. Mix with a full glass of liq.
• Child: ≤12 yr Each level 5-mL spoonful contains 1.75 g: Half to 1 level 5-mL spoonful bid (morning and evening) to be dissolved in water.

Mild to moderate hypercholesterolaemia:

• Adult: As adjunct to lipid-lowering diet: 7.5-10 g daily. Mix with a full glass of liq.

Administration

It’s best to take it on an empty stomach. Take with a full glass of water before meals.

Interaction

Licorice, laxatives, and antidiabetic medications used together may raise the risk of hypokalemia and hypoglycemia. The bioavailability of carbamazepine may be decreased when psyllium seed is taken at the same time.

Contraindications

Pre-existing faecal impaction, intestinal blockage, natural or drug-induced decrease in gut motility, and colonic atony, such as senile megacolon.

Side Effects

Exanthema and/or pruritus; hypersensitivity responses such as rhinitis, conjunctivitis, bronchospasm, and anaphylaxia; abdominal distention, flatulence, GI impaction, GI blockage; cutaneous symptoms (e.g. exanthema and/or pruritus).

Pregnancy & Lactation

There have been no documented side effects in pregnancy or lactation.

Precautions & Warnings

Patient has trouble swallowing. Children.

Therapeutic Class

Herbal and nutraceuticals, as well as bulk-forming laxatives

Storage Conditions

Keep the temperature below 30° C.

Pharmaceutical Name

Drug International Ltd.