Description
Generic
Ketotifen Fumarate
Indications
- Prophylaxis of bronchial asthma.
- Allergic minutes (seasonal and perennial).
- Allergic conjunctivitis.
Pharmacology
Ketotifen has anti-allergic characteristics and has been utilized in the preventative treatment of asthma in a similar way to sodium cromoglycate. It has antihistamine characteristics as well. Ketotifen has strong anti-anaphylactic effects and is useful for avoiding asthma attacks. Ketotifen has a long-lasting inhibitory effect on histamine reactions, which is distinct from its anti-anaphylactic effects. Ketotifen is as effective orally as a selective mast cell stabilizer delivered by inhalation in asthmatic individuals, according to research. In such tests, antihistamines were unsuccessful. Long-term clinical trials have been conducted to determine the efficacy of Ketotifen. The number, severity, and length of asthma attacks were reduced, and in some cases, the patients were completely free of attacks. It was also possible to gradually reduce corticosteroids and/or bronchodilators. It may take several weeks for Ketotifen’s prophylactic activity to become fully established. Ketotifen will not stop an asthma episode that has already started.
Dosage & Administration
Adults should take 1 mg twice a day with food. In severe situations, the dose can be increased to 2 mg twice daily if necessary.
Children over the age of three should take 1 mg twice a day with food. For the first few days, or as indicated by the physician, patients who are easily sedated should start with 0.5 to 1 mg at night.
In the elderly, use the same dose as adults or as directed by a physician. avoided.
Interaction
Sedatives, hypnotics, antihistamines, and alcohols may be amplified by ketotifen. A reversible decrease in platelet count has been documented in a few patients taking Tiffen with oral antidiabetic medications, leading to the recommendation that this combination is avoided.
Contraindications
hypersensitivity to Ketotifen or any other components of the formulation Patients sensitive to Benzoate mounds should not take Ketotifen.
Side Effects
Drowsiness associated with occasional dry mouth and slight dizziness may occur at the beginning of treatment but usually disappears after few days.
Pregnancy & Lactation
Ketotifen is not indicated during pregnancy or lactation, despite the lack of evidence of teratogenic effects.
Precautions & Warnings
To avoid an asthma exacerbation, it is critical to continue the previous medication for at least two weeks after commencing Ketotifen. Because of the possibility of adrenocortical insufficiency in steroid-dependent patients, this is especially true for systemic corticosteroids and ACTH. Ketotifen treatment must be complemented by specialized antibiotic therapy if intercurrent infection occurs. Reactions may be impaired on the first day of Ketotifen medication, and patients should be advised not to drive or operate machinery until the effects of Ketotifen treatment on the person are known. Patients should be encouraged to stay away from alcoholic beverages. Sedatives, hypnotics, antihistamines, and alcohol may be amplified by ketotifen.
Therapeutic Class
Cromoglycate and its derivatives.
Storage Conditions
Protect from light and store in a cool, dry location. Keep out of children’s reach.
Pharmaceutical Name
ACME Laboratories Ltd.
