Iprasol Hfa .


Iprasol Hfa .


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This inhalation aerosol is intended for use in patients with chronic obstructive pulmonary disease (COPD) who are using a regular aerosol bronchodilator but still experience bronchospasm and need a second bronchodilator.


Salbutamol (as Sulphate) and Ipratropium Bromide are combined in this inhalation aerosol. It is an environmentally friendly inhaler based on hydrofluoroalkane (HFA). Because it does not utilize chlorofluorocarbon (CFC) propellant, which is one of the primary causes of ozone layer depletion.

Salbutamol is a beta2-adrenergic bronchodilator with a short half-life, while Ipratropium Bromide is an anticholinergic bronchodilator. Ipratropium Bromide, when taken in combination, inhibits the rise in intracellular concentration of cyclic guanosine monophosphate induced by acetylcholine contact with the muscarinic receptor on bronchial smooth muscle. This inhalation aerosol is intended to improve treatment responsiveness in patients with chronic obstructive pulmonary disease (COPD) by decreasing bronchospasm via two separate mechanisms: anticholinergic (parasympatholytic) and sympathomimetic. The simultaneous use of an anticholinergic (Ipratropium Bromide) and a beta 2-sympathomimetic (Salbutamol) is intended to assist the patient by providing a stronger bronchodilatory effect than either medication alone at the indicated dosage.


Adult dose (Including the elderly): 2 puffs of Salpium 4 times a day (Patients may take additional puffs as required but the total number of puffs should not exceed 12 in 24 hours). Or as directed by the physician.


Using an Inhaler seems simple, but most patients do not know how to use it in the right way. If the Inhaler is used in the wrong way, less medicine can reach the lungs. Correct and regular use of the Inhaler will prevent or lessen the severity of asthma attacks.

Following simple steps can help to use Inhaler effectively (According to “National Asthma Guidelines for Medical Practitioners” published by Asthma Association):

  • Take off the cap.
  • Shake the inhaler (at least six times) vigorously before each use.
  • If the inhaler is new or if it has not been used for a week or more, shake it well and release one puff into the air to make sure that it works.
  • Breathe out as fully as comfortably possible & hold the inhaler upright.
  • Place the actuator into the mouth between the teeth and close the lips around the mouthpiece.
  • While breathing deeply and slowly through the mouth, press down firmly and add fully to the canister to release medicine.
  • Remove the inhaler from the mouth. Continue holding your breath for at least 10 seconds or as long as it is comfortable.
  • If the doctor has prescribed more than one inhalation per treatment, wait 1 minute between puffs (inhalations). Shake the inhaler well and repeat steps 4 to 7.
  • After use, replace the cap on the mouthpiece. After each treatment, rinse your mouth with water.
  • Check your technique in front of a mirror from time to time, if you see a white mist during the inhalation, you may not have closed your lips properly around the mouthpiece, or you may not be breathing in as you press the can. This indicates a failure of the technique. If this happens, repeat the procedure from step 4 carefully.

Instructions for Cleaning Inhaler: Clean your Inhaler at least once a week. Remove the canister and rinse the plastic actuator and cap in warm water but do not put the metal canister into water. Dry the actuator and cap thoroughly and gently replace the metal canister into the actuator with a twisting motion. Put the cap on the mouthpiece.


This inhalation aerosol has been used in conjunction with other medications widely used in the treatment of COPD, such as sympathomimetic bronchodilators, methylxanthines, and steroids. There have been no official drug interaction studies with this inhalation aerosol and these or other medicines frequently used in the treatment of COPD. Ipratropium Bromide should be used with caution when combined with other anticholinergic and sympathomimetic medicines, since this may raise the risk of serious cardiovascular consequences. In patients using non-potassium-sparing diuretics, monoamine oxidase inhibitors, or tricyclic antidepressants, beta-2-agonist-containing medicines, such as this inhalation aerosol, should be used with great caution.


This inhalation aerosol is contraindicated in patients with a history of hypersensitivity to Soya-Lecithin or related food products such as soybean and peanut. This inhalation aerosol is also contraindicated in patients hypersensitive to any other components of the drug product or to atropine or its derivatives.

Side Effects

Mild tremors and headaches have been observed as a result of the presence of Salbutamol. These generally go away with consistent therapy. There have been relatively few reports of muscular cramps, and hypersensitivity responses such as angioedema, urticaria, bronchospasm, and hypotension as a result of therapy.

Headache, influenza, chest discomfort, nausea, dyspnea, coughing, pharyngitis, and sinusitis are infrequently observed in the presence of Ipratropium Bromide.

Pregnancy & Lactation

Pregnancy category B for ipratropium bromide. Ipratropium has been shown in studies to have no teratogenic effects.

Pregnancy category C for salbutamol. Salbutamol has been proven in animal studies to be teratogenic.

However, there have been no appropriate and well-controlled trials using Salpium Inhalation Aerosol (a mixture of salbutamol and ipratropium bromide) in pregnant women. During pregnancy, this inhalation aerosol should be used only if the possible benefit outweighs the potential danger to the baby. It is unknown whether the Salpium InhalationAerosol components are excreted in human milk. Salpium should be provided with caution to a nursing mother because many medications are excreted in human milk.

Therapeutic Class

Bronchodilators in combination

Storage Conditions

Even if the pressurized canister seems to be empty, do not puncture, shatter, or incinerate it. Store in a cool, dry place away from direct sunlight or heat. Keep in a cool, dry place. Keep children at a distance. Keep your hands away from your eyes.


Salbutamol + Ipratropium

Pharmaceutical Name

Beximco Pharma Ltd