Description
Generic
Indications
Indomethacin is indicated for the treatment of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis (degenerative joint disease), gout, acute non-articular rheumatism (bursitis, synovitis, tendinitis).
Pharmacology
Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) having properties of antipyretic and analgesic effects. A great number of pharmacological studies have proved that Indomethacin has strong anti-inflammatory, analgesic and antipyretic properties. Unlike the corticosteroids, the effect of Indomethacin is not related to the pituitary gland or the adrenals.
Administration & Dosage
100 mg at night and in the morning if required.
Interaction
It may interact with anticoagulants, lithium, diuretics, Beta-blockers, diflunisal, aspirin, probenecid and sulfonylureas.
Contraindications
It is contraindicated in previously hypersensitive patient.
Side Effects
Headache, usually in the morning and mild vertigo may occur during the early weeks of therapy. These symptoms are transient and usually disappear with continued use or by reduction of the dose. Gastrointestinal reactions such as nausea, vomiting, diarrhea, epigastric and abdominal pain are often due to large doses of the drug and disappear when the dose is reduced.
Pregnancy & Lactation
Not recommended for pregnant women, because at the present time clinical studies are insufficient.
Precautions & Warnings
In patients with epilepsy (avoid if poorly controlled, discontinue if convulsions develop), concurrent electroconvulsive therapy (prolonged seizures reported with fluoxetine), history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase bleeding risk, and history of bleeding disorders, SSRIs should be used with caution.
Therapeutic Class
Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children’s reach.
