Gliclid MR 60 MG


Gliclid MR 60 MG


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Patients with maturity-onset diabetes mellitus (NIDDM) who require an oral hypoglycaemic medication should use gliclazide.



Gliclazide is a sulfonylurea of the second generation with hypoglycemic and perhaps hematological effects. It reduces hepatic glucose output while stimulating insulin release from pancreatic -cells by promoting Ca+2 transport across the -cell membranes.


Dosage & Administration

Film coated tablet: The usual initial dose is 40 to 80 mg daily. The dose can be increased upto 320 mg daily in divided doses when needed. The drug should be taken before meal. For children Gliclazide is not used because it is contraindicated in juvenile-onset diabetes.

Modified release preparation: The usual daily dosage for Gliclazide 30 mg is 1 to 4 tablets & Gliclazide 60 mg is 1 to 2 tablets per day as a single dose. It is recommended that the drug should be taken at breakfast time. It is preferable to take this drug before breakfast in order to avoid or to minimize the possible onset of digestive disorders.



Aspirin, NSAIDs, Phenylbutazone, Clofibrate, Sulfonamide, Cimetidine, Imidazole antifungal medications, and Monoamine Oxidase inhibitors may exacerbate Gliclazide’s hypoglycaemic effects. Rifampin, Barbiturates, Phenytoin, Thiazide diuretics, Diazoxide, Glucocorticoids, Estrogens, Sympathomimetic medications, and Alcohol may diminish the hypoglycaemic impact of Gliclazide.



Gliclazide should not be used in the following conditions: Juvenile-onset (type-1) diabetes Diabetes with Ketosis

Diabetic individuals having surgery, recovering from a serious accident, or in the midst of an infection

Patients who are hypersensitive to the sulfonylurea medication class

Pregnant ladies and mothers who are breast-feeding

Hepatic insufficiency is a condition in which the liver is unable to function properly.


Side Effects

Hypoglycemia can occur in the presence of other illnesses such as hepatic and renal dysfunction, starvation, and alcohol consumption. Headaches, gastrointestinal problems, nausea, dizziness, and skin reactions such as rash, pruritus, and erythema are all possible side effects.


Pregnancy & Lactation

Pregnant women should avoid taking gliclazide. It should not be used by a mother who is breastfeeding.


Precautions & Warnings

In patients with hepatic impairment, gliclazide should be administered with caution. Gliclazide should not be used if there is clear evidence of liver illness. Because gliclazide is thoroughly metabolized, it can be taken safely in patients with renal failure. Gliclazide has a lower risk of hypoglycemia than the other sulfonylurea medications.


Therapeutic Class



Storage Conditions

Store below 30°C and away from light in a cool, dry location.


Pharmaceutical Name

ACME Laboratories Ltd.