Indications of Geflox 500 Tablet

Respiratory tract infections

• Ear, nose, and throat infections
• Eye infections
• Urinary tract infections
• skin and soft tissue infections
• Bone and joint infections

Pharmacology of Geflox 500 Tablet

Ciprofloxacin is a synthetic fluoroquinolone drug. It has bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It inhibits bacterial DNA synthesis by combining with the bacterial enzymes DNA gyrase and topoisomerase IV responsible for DNA supercoiling.

Dosage of Geflox 500 Tablet

Tablet: Adult:

Respiratory Tract Infections: 500 to 750 mg twice daily (7 to 14 days)

Urinary tract infections: 250 to 750 mg twice daily (3 to 10 days)

Pelvic Inflammatory Diseases: 500 to 750 mg twice daily (14 days)

Infectious Diarrhea (Shigella dysenteriae, Vibrio cholera): 500 mg twice daily (1 to 5 days)

Typhoid fever: 500 mg twice daily (7 days)

Intra-abdominal infections: 500 to 750 mg twice daily (5 to 14 days)

Prostatitis: 500 to 750 mg twice daily (2 to 6 weeks)

Skin and Soft Tissue Infections: 500 to 750 mg twice daily (7 to 14 days)

Bone and Joint Infections: 500 to 750 mg twice daily (max. 3 months)

Gonorrhea: 500 mg as a single dose

Neutropenic patients with fever due to bacterial infection: 500 to 750 mg twice daily co-administered with appropriate antibacterials.

Meningitis: 500 mg as a single dose.

Surgical prophylaxis: 500 mg as a single dose, 60 minutes before the procedure.

Suspension: Pediatric: 10-20 mg/kg (max. 750 mg) twice daily (10 to 21 days). The duration of therapy depends on the type and severity of the infection.

Extended-release tablet: In uncomplicated urinary tract infection (acute cystitis), the recommended dose of extended-release tablet is 1000 mg tablet once daily for three days.

For IV infusion:

Urinary Tract Infection: Mild to Moderate: 200 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 12 hourly for 7-14 days

Lower Respiratory Tract infection: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days

Nosocomial Pneumonia: Mild/Moderate/Severe: 400 mg 8 hourly for 10-14 days

Skin and Skin Structure: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days

Bone and Joint Infection: Mild to Moderate: 400 mg 12 hourly for more than 4-6 weeks; Severe/Complicated: 400 mg 8 hourly for more than 4-6weeks

Intraabdominal (Acute abdomen): Complicated: 400 mg 12 hourly for 7-14 days

Acute Sinusitis: Mild/Moderate: 400 mg 12 hourly for 10 days

Chronic Bacterial Prostatitis: Mild/Moderate: 400 mg 12 hourly for 28 Days.

Administration of Geflox 500 Tablet

Instruction for the use of Ciprofloxacin IV infusion-

• Check the bag for minute leaks by squeezing the inner bag firmly. If leaks are found, or if seal is not intact, discard the solution.
• Do not use if the solution is cloudy or a precipitate is present.
• Do not use flexible bags in series connections.
• Close flow control clamp of administration set.
• Remove cover from port at bottom of bag.
• Insert piercing pin of administration set into port with a twisting motion until the pin is firmly seated.
• Suspend bag from hanger.
• Squeeze and release drip chamber to establish proper fluid level in chamber during infusion of Ciprofloxacin IV infusion.
• Open flow control clamp to expel air from set.Close clamp.
• Regulate rate of administration with flow control clamp

Duration of treatment: The duration of treatment depends upon the severity of infection, clinical response and bacteriological findings. For acute infections the usual treatment period is 5 to 10 days. Generally treatment should be continued for 3 days after the signs and symptoms of the infection have been disappeared.

Interaction of Geflox 500 Tablet

When Ciprofloxacin tablet is given concomitantly with food, there is a delay in the absorption of the drug whereas there is no delay observed when Ciprofloxacin suspension is given with food. Concurrent administration of antacids containing magnesium hydroxide or aluminum hydroxide may reduce the bioavailability of Ciprofloxacin by as much as 90%. Ciprofloxacin may increase the effects of theophylline

Contraindications

Ciprofloxacin is contraindicated in patients who have shown hypersensitivity to Ciprofloxacin.

Side Effects of Geflox 500 Tablet

Ciprofloxacin is generally well tolerated. The most frequently reported adverse reactions are nausea, diarrhea, vomiting, abdominal pain, discomfort, headache, restlessness and rash.

Pregnancy & Lactation

Not recommended.

Precautions & Warnings

Ciprofloxacin should be used with caution in epileptics and patients with a history of CNS disorders and only if the benefits of the treatment are considered to outweigh the risk of possible CNS side effects. Alteration of the dosage regimen is necessary for patients with impaired renal function.

Therapeutic Class

4-Quinolone preparations, Anti-diarrhoeal Antimicrobial drugs

Storage Conditions

Store in a cool and dry place, protect from light and out of children’s reach. Discard the reconstituted suspension of unused portion after 14 days.

Pharmaceutical Name of Geflox 500 Tablet

General Pharmaceuticals Ltd

Generic of Geflox 500 Tablet

Ciprofloxacin