Generic

Fluconazole

Indications

Fluconazole is indicated for the treatment of vaginal candidiasis, oropharyngeal and esophageal candidiasis, and Curiputococcal meningitis. It is also effective in the treatment of urinary tract infections caused by Candida peritonitis, and systemic candidiasis (candidiasis, disseminated candidiasis, pneumonia, etc.).

Pharmacology

Fluconazole is a triazole antifungal agent. It is a potent inhibitor of cytochrome P450-dependent fungal enzymes. The cytochrome P450 enzyme system is an essential component of fungal cell membranes, responsible for the synthesis of ergosterol.

Dosage & Administration

Adult (oral)-

Vaginal candidiasis: 150 mg as a single dose.

Oropharyngeal candidiasis: 200 mg on the first day, followed by 100 mg once daily. Clinical evidence of this infection generally resolves within several days, but treatment should be continued for at least 2 weeks to decrease the likelihood of relapse.

Esophageal candidiasis: 200 mg on the first day, followed by 100 mg once daily. Doses up to 400 mg/day may be used. Patients should be treated for a minimum of three weeks and for at least two weeks following the resolution of symptoms.

Systemic candida infections: Optimal therapeutic dosage and duration of therapy have not been established. Sometimes, doses of up to 400 mg daily have been used.

Urinary tract infections caused by candida and peritonitis: 50-200 mg daily have been used.

Cryptococcal meningitis: 400 mg on the first day, followed by 200 mg once daily.

Prophylaxis in patients undergoing bone marrow transplantation: 400 mg once daily.

Child (oral):

Doses of 3-6 mg/kg daily have been used. Doses up to 12 mg/kg are recommended.

Intravenous-

Adult: Invasive candidal infections including candidaemia and disseminated candidiasis and cryptococcal infections including meningitis, by IV, 400 mg initially then 200 mg daily, increased if necessary to 400 mg daily, treatment continued according to response (at least 6-8 weeks for cryptococcal meningitis)

Child: 6-12 mg/kg daily (every 72 hours in neonate up to 2 weeks old, every 48 hours in neonate 2-4 weeks old); maximum 400 mg daily. Prevention of relapse of cryptococcal meningitis, by IV, 100-200 mg daily.

Interactions

Concomitant use of ciclosporin or phenytoin with fluconazole increases plasma concentrations of ciclosporin or phenytoin. Concomitant use of fluconazole and warfarin prolongs prothrombin time. Rifampicin levels are reduced when used with fluconazole.

Contraindications

Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.

Side Effects

Fluconazole is well tolerated. The most common side effects of using Fluconazole include nausea, vomiting, abdominal pain, diarrhea, headache, and skin rash.

Pregnancy & Lactation

The US FDA Pregnancy Category for fluconazole is C. Therefore, fluconazole should be avoided during pregnancy and lactation, unless the potential benefits of the other type outweigh those possible risks to the fetus.

Precautions & Warnings

Fluconazole should be administered with caution to patients having proarrhythmic conditions.

Therapeutic Class

Drugs for subcutaneous and mycoses

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Pharmaceutical Name

Square Pharmaceuticals Ltd.