Description
Generic
Fexofenadine Hydrochloride
Indications
Fexofenadine Hydrochloride is used to treat the symptoms of seasonal allergic rhinitis in both adults and children. It’s also used to treat the cutaneous symptoms of chronic idiopathic urticaria that aren’t too severe.
Pharmacology
Fexofenadine Hydrochloride is an antihistamine that works by blocking peripheral H1 receptors. After oral administration, it is quickly absorbed and reaches maximal plasma concentration in 2-3 hours. It doesn’t appear to be able to pass through the blood-brain barrier.
Dosage & Administration
Seasonal Allergic Rhinitis-
Adults and children 12 years and older:
- Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
- In case of impaired renal function: 60 mg once daily
Children from 6 to 11 years:
- Tablet: 30 mg twice daily or 60 mg once daily
- In case of impaired renal function: 30 mg once daily
Children from 2 to 11 years
- Suspension: 30 mg or 5 ml twice daily
- In case of impaired renal function: 30 mg or 5 ml once daily
Chronic Idiopathic Urticaria-
Adults and children 12 years and older:
- Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
- In case of impaired renal function: 60 mg once daily
Children from 6 to 11 years:
- Tablet: 30 mg twice daily or 60 mg once daily
- In case of impaired renal function: 30 mg once daily
Children from 6 months to less than 2 years:
- Suspension: 15 mg or 2.5 ml (1/2 tsp) twice daily
- In case of impaired renal function: 15 mg or 2.5 ml (1/2 tsp) once daily
Children from 2 to 11 years:
- Suspension: 30 mg or 5 ml (1 tsp) twice daily
- In case of impaired renal function: 30 mg or 5 ml (1 tsp) once daily
Interaction
When administered with erythromycin or ketoconazole, the plasma levels of Fexofenadine Hydrochloride increased. Fexofenadine Hydrochloride absorption is reduced by antacids that include aluminum and magnesium hydroxide.
Contraindications
Patients who have a known hypersensitivity to Fexofenadine Hydrochloride or any of its components should not use it.
Side Effects
Headache, tiredness, sleepiness, nausea, dry mouth, and gastrointestinal problems are all common adverse effects.
Pregnancy & Lactation
Fexofenadine Hydrochloride is classified as pregnancy category C by the US Food and Drug Administration. So, unless the potential advantages to the other outweigh the potential dangers to the fetus, Fexofenadine Hydrochloride should be avoided during pregnancy and breastfeeding.
Precautions & Warnings
Patients who are old or have impaired renal function should be treated with caution.
Therapeutic Class
Non-sedating antihistamines
Storage Conditions
Store away from light and heat in a cool, dry area. Children should be kept out of reach.
Pharmaceutical Name
Incepta Pharmaceuticals Ltd.