Extranil 5 MG


Extranil 5 MG


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Procyclidine Hydrochloride



All forms of Parkinson’s disease e.g.

  • Idiopathic parkinsonism
  • Post-encephalitic parkinsonism
  • Arteriosclerotic parkinsonism

Extrapyramidal symptoms e.g.

  • Pseudo-parkinsonism
  • Acute dystonic reactions
  • Akathisia induced by neuroleptic drugs such as phenothiazine derivatives



Procyclidine hydrochloride is an antimuscarinic drug for Parkinson’s disease with relatively low toxicity. It is a synthetic tertiary amine. This drug exerts its anti-Parkinson’s effect by correcting relative cholinergic excess, which is believed to be caused by dopamine deficiency. Quickly disappeared from G.I. and the organization. After intravenous administration, it takes effect in 5-20 minutes and lasts up to 4 hours.


Dosage & Administration


  • Parkinsonism : Initially 2.5 mg 3 times daily, increasing by 2.5-5 mg daily at intervals of 2 or 3 days until the optimum clinical response is achieved. The usual maximum dose is 30 mg daily in divided doses and may be increased upto 60 mg daily in divided doses.
  • Drug induced extrapyramidal symptom: Initially 2.5 mg 3 times daily. The dosage being increased by 2.5 mg per day as needed and tolerated. Maximum 20 mg daily can be given.

Injection: By intramuscular or intravenous injection, 5-10 mg, repeated if necessary after 20 minutes; maximum 20 mg daily can be given.



Phenothiazines, anticonvulsants, levodopa, ketoconazole, monoamine oxidase inhibitors, adsorbent, antidiarrhoeals, alcohol, anticholinergic drugs.



Tardive dyskinesia and the patients those are hypersensitive to Procyclidine.


Side Effects

Dryness of mouth, blurring of vision, giddiness, gastro-intestinal disturbances (nausea, vomiting, epigastriac distress, constipation), allergic reaction (e.g. rash) or muscular weakness may occasionally occur. High doses may cause vertigo and possible confusion and hallucination; Side e­ects may usually be minimized by adjustment of dosage and administration after meal.


Pregnancy & Lactation

No data is advisable on the safe use of this drug in pregnancy and lactation.


Precautions & Warnings

It should be given with caution in children & geriatric patients. It is advisable to be cautious in giving Procyclidine to patients with diarrhea and cardiovascular diseases, glaucoma, urinary retention, hepatic or renal impairment.


Therapeutic Class

Antiparkinson drugs


Storage Conditions

Store in a cool and dry place, away from light. Keep out of the reach of children


Pharmaceutical Name

General Pharmaceuticals Ltd.