Don-A 60 ML


Don-A 60 ML


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Indications of Don-A 60 ml

Delayed stomach emptying, gastroesophageal reflux, and esophagitis are all symptoms of dyspeptic symptom complex.

Upper abdominal pain, feeling of abdominal distension, and epigastric fullness

  • Eructation, flatulence, and early satiety are all symptoms of early satiety.
  • Vomiting and nausea
  • Regurgitation of stomach contents into the mouth, with or without heartburn
  • Dyspepsia without ulcers

Acute nausea and vomiting of functional, organic, infectious, or dietetic origin, as well as nausea and vomiting generated by radiotherapy or pharmacological therapy, and nausea and vomiting induced in migraine.

Dopamine agonist-induced nausea and vomiting in Parkinson’s disease.

Increasing the speed of barium transit in follow-up radiological tests.


Pharmaceutical Name of Don-A 60 ml

ACME Laboratories Ltd.



Domperidone may be a dopamine enemy that principally pieces the dopamine receptors found within the ChemoreceptorTrigger Zone (CTZ) and stomach. Its gastroprokinetic activity is based on its blocking impact of dopamine receptors that have an impact on the motility of the gastrointestinal tract. Due to its frail entrance over the blood-brain barrier, Domperidone has nearly no impact on the dopaminergic receptors within the brain, subsequently, barring psychotropic and neurologic side impacts. Domperidone reestablishes ordinary motility and tone of the upper gastrointestinal tract, encourages gastric purging, improves antral and duodenal peristalsis and directs withdrawal of the pylorus. Domperidone moreover increments esophageal peristalsis and lower esophageal sphincter weight, and in this way avoids spewing forth of gastric content.


Dosage & Administration

Domperidone should be taken 15-30 minutes before meals and, if necessary, before retiring.

The usual recommended oral dose of Domperidone is as follows:

  • Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
  • Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily.

In dyspeptic symptom:

  • Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily.
  • Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

  • Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
  • Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

By rectum in suppositories:

  • Adults (including elderly): 30-60 mg every 4-8 hours.
  • Children: The maximum daily dose rectally in children’s is 30 mg for those weighting 10 to 25 kg. The dose may be divided throughout day if necessary.
  • The maximum period of treatment is 12 weeks.


Interaction of Don-A 60 ml

Bromocriptine’s hypoprolactemic impact may be reduced by domperidone. Antimuscarinics and opoid analgesics may counteract Domperidone’s effect on Gl function. When domperidone is used with MAO (monoamine oxidase) inhibitors, caution should be exercised.



Domperidone is not recommended for patients who have a known hypersensitivity to the medicine or for neonates. When gastrointestinal stimulation is potentially harmful, such as gastrointestinal hemorrhage, mechanical obstruction, or perforation, do not use domperidone. Patients with a prolactin-releasing pituitary tumor are also advised against taking it (prolactinoma).


Side Effects of Don-A 60 ml

Hyperprolactinemia is a side effect of domperidone (1.3 percent ). Galactorrhea, breast growth, discomfort, and a decrease in libido are all possible side effects. During domperidone treatment, dry mouth (1 percent), thirst, headache (1.2 percent), nervousness, drowsiness (0.4 percent), diarrhea (0.2 percent), skin rash, and itching (0.1 percent) are all possible side effects. Clinical investigations show that extrapyramidal responses occur in 0.05 percent of patients.


Pregnancy & Lactation

Because the safety of domperidone has not been established, it is not recommended for use during pregnancy. The teratogenic effect in the fetus has not been shown in animal research. Domperidone can help with galactorrhea and postpartum lactation. It’s secreted in breast milk, but in such small amounts that it’s not considered dangerous.


Precautions & Warnings

Domperidone should be used with extreme caution in children due to an elevated risk of extrapyramidal effects due to an incompletely established blood-brain barrier in young children. Domperidone should be taken with caution in patients with hepatic impairment since it is highly metabolized in the liver.


Therapeutic Class

Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs


Storage Conditions

Store below 30°C, Protected from light & moisture. Keep out of children’s reach.


Generic of Don-A 60 ml

Domperidone Maleate