Don-A 15 ML


Don-A 15 ML


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Indications of Don-A 15 ml

Dyspeptic symptom complex, often associated with delayed gastric emptying, gastroesophageal reflux and esophagitis:

  • Epigastric sense of fullness, the feeling of abdominal distension, upper abdominal pain
  • Eructation, flatulence, early satiety
  • Nausea and vomiting
  • Heartburn with or without regurgitations of gastric contents in the mouth
  • Non-ulcer dyspepsia


Pharmaceutical Name of Don-A 15 ml

ACME Laboratories Ltd.


Domperidone could be a dopamine adversary that principally squares the dopamine receptors found within the ChemoreceptorTrigger Zone (CTZ) and stomach. Its gastroprokinetic activity is based on its blocking impact of dopamine receptors that have an impact on the motility of the gastrointestinal tract. Due to its frail entrance over the blood-brain barrier, Domperidone has nearly no impact on the dopaminergic receptors within the brain, in this mannerbarring psychotropic and neurologic side impacts. Domperidone reestablishes typical motility and tone of the upper gastrointestinal tract, encourages gastric purgingupgrades antral and duodenal peristalsis and controls compression of the pylorus. Domperidone moreover increments esophageal peristalsis and lower esophageal sphincter weight, and in this way anticipates spewing forth of gastric substance.


Administration & Dosage

The usual recommended oral dose of Domperidone is as follows:

  • Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
  • Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily.

In dyspeptic symptom:

  • Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily.
  • Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

  • Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
  • Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

By rectum in suppositories:

  • Adults (including elderly): 30-60 mg every 4-8 hours.
  • Children: The maximum daily dose rectally in children’s is 30 mg for those weighting 10 to 25 kg. The dose may be divided throughout day if necessary.
  • The maximum period of treatment is 12 weeks.


Interaction of Don-A 15 ml

Domperidone may reduce the risk of hypoprolactemic effect of bromocriptine. The action of Domperidone on Gl function may be antagonized by antimuscarinics and opoid analgesics. Care should be exercised when domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.



Domperidone is contraindicated to patients having known hypersensitivity to this drug and in the case of neonates. Domperidone should not be used whenever gastrointestinal stimulation might be dangerous i.e., gastrointestinal hemorrhage, mechanical obstruction or perforation. Also contraindicated in patients with prolactin releasing pituitary tumor (prolactinoma).


Side Effects of Don-A 15 ml

Domperidone may produce hyperprolactinemia (1.3%).This may result in galactorrhea, breast enlargement, and soreness and reduced libido. Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash and itching (0.1%) may occur during treatment with domperidone. Extra-pyramidal reactions are seen in 0.05% of patients in clinical studies.


Pregnancy & Lactation

The safety of domperidone has not been proven and it is therefore not recommended during pregnancy. Animal studies have not demonstrated the teratogenic effect in the fetus. Domperidone may precipitate galactorrhea and improve post-natal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.


Precautions & Warnings

Domperidone should be used with absolute caution in the case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood-brain barrier. Since domperidone is highly metabolized in liver, it should be used with caution in patient with hepatic impairment.


Therapeutic Class

Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs


Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children’s reach.


Generic of Don-A 15 ml

Domperidone Maleate