Indications of Domin 15 ml

A complex of dyspeptic symptoms, generally associated with delayed gastric emptying, gastroesophageal reflux, and esophagitis:

• Fullness, abdominal distention, upper abdominal pain
• Belching, flatulence, early satiety
• Nausea and vomiting
• Heartburn with or without gastric reflux in the mouth
• Dyspepsia non-ulcer
• Acute, functional, organic, infectious nausea and vomiting, of dietary origin or induced by radiotherapy or pharmacotherapy or induced by migraine.
• Parkinson’s disease: nausea and vomiting caused by dopamine receptor agonists.
• Radiology Research: Accelerating Barium Transport in Follow-up Radiology Research.

Pharmaceutical Name of Domin 15 ml

Pharmacology

Domperidone is a dopamine antagonist that mainly blocks dopamine receptors located in the chemoreceptor activation zone (CTZ) and stomach. Its gastrointestinal motility is based on its blocking effect on dopamine receptors that affect gastrointestinal motility. Due to its weak permeability to the blood-brain barrier, domperidone has almost no effect on dopamine receptors in the brain, thus eliminating mental and neurological side effects. Domperidone restores the normal movement and tension of the upper gastrointestinal tract, promotes gastric emptying, improves gastric antrum and duodenal peristalsis, and regulates pyloric contraction. Domperidone also increases esophageal motility and reduces esophageal sphincter pressure, thereby preventing the reflux of stomach contents.

Dosage & Administration

Domperidone should be taken 15-30 minutes before meals and, if necessary, before retiring.

The usual recommended oral dose of Domperidone is as follows:

• Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
• Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight, every 6-8 hours daily.

In dyspeptic symptoms:

• Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily.
• Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml pediatric drops/10 kg) body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

• Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
• Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml pediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

By rectum in suppositories:

• Adults (including elderly): 30-60 mg every 4-8 hours.
• Children: The maximum daily dose rectally in children is 30 mg for those weighing 10 to 25 kg. The dose may be divided throughout the day if necessary.
• The maximum period of treatment is 12 weeks.

Interaction of Domin 15 ml

Domperidone can reduce the risk of bromocriptine-causing hypo prolactin. The effect of domperidone on GI function can be antagonized by antimuscarinic drugs and opioid analgesics. Caution should be exercised when domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.

Contraindications

Domperidone is contraindicated in patients and newborns who are known to be allergic to this drug. Domperidone should not be used when gastrointestinal irritation could be dangerous, ie gastrointestinal bleeding, mechanical obstruction or perforation. Prolactin-releasing pituitary tumors (prolactinomas) are also contraindicated.

Side Effects of Domin 15 ml

Domperidone can cause hyperprolactinemia (1.3%). This can cause galactorrhea, breast enlargement, pain, and decreased libido. Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), rash and itching ( 0.1%). In clinical studies, 0.05% of patients had extrapyramidal reactions.

Pregnancy & Lactation

The safety of domperidone has not been proven, so its use during pregnancy is not recommended. Animal studies have not shown teratogenic effects on the fetus. Domperidone can cause galactorrhea and improve postpartum lactation. It is secreted in breast milk, but the amount is very small and not enough to be considered harmful.

Precautions & Warnings

The safety of domperidone has not been proven, so its use during pregnancy is not recommended. Animal studies have not shown teratogenic effects on the fetus. Domperidone can cause galactorrhea and improve postpartum lactation. It is secreted in breast milk, but the amount is very small and not enough to be considered harmful.

Therapeutic Class

Motility Stimulants, Motility stimulants/Dopamine antagonists, Prokinetic drugs

Storage Conditions

Store at or below 30°C, away from light and moisture. Keep out of reach of youngsters.