Indications of Domin 10 mg Tablet

Dyspeptic symptom complex, frequently accompanied by delayed stomach emptying, gastroesophageal reflux, and esophagitis:

• Fullness in the epigastric region, abdominal distension, and upper abdominal discomfort
• Flatulence, eructation, and early satiety
• Vomiting and nausea
• Regurgitation of stomach contents in the mouth, with or without heartburn
• Dyspepsia without ulcers

Acute nausea and vomiting of functional, organic, infectious, or dietary origin, or caused by radiation or medication therapy, or caused by migraine. Parkinson’s disease is characterized by dopamine agonist-induced nausea and vomiting. Radiological investigations: Accelerating barium transit in subsequent radiological examinations.

Pharmaceutical Name of Domin 10 mg Tablet

Opsonin Pharma Limited

Pharmacology

Domperidone is a dopamine antagonist that works primarily by blocking dopamine receptors in the chemoreceptor trigger Zone (CTZ) in the stomach. Its gastroprokinetic activity is based on its ability to inhibit dopamine receptors, which regulate gastrointestinal motility. Domperidone has practically little action on dopaminergic receptors in the brain due to its poor penetration across the blood-brain barrier, omitting psychotropic and neurologic adverse effects. Domperidone restores normal upper gastrointestinal motility and tone, aids stomach emptying, improves antral and duodenal peristalsis, and controls pylorus contraction. Domperidone also enhances esophageal peristalsis and decreases esophageal sphincter pressure, preventing gastric content regurgitation.

Dosage & Administration of Domin 10 mg Tablet

Domin 10 mg tablet should be taken 15-30 minutes before meals and, if necessary, before retiring.

The usual recommended oral dose of Domperidone is as follows:

• Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
• Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight, every 6-8 hours daily.

In dyspeptic symptoms:

• Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily.
• Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml pediatric drops/10 kg) body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

• Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
• Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml pediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

By rectum in suppositories:

• Adults (including elderly): 30-60 mg every 4-8 hours.
• Children: The maximum daily dose rectally in children is 30 mg for those weighing 10 to 25 kg. The dose may be divided throughout the day if necessary.
• The maximum period of treatment is 12 weeks.

Interaction of Domin 10 mg Tablet

Domin 10 mg may lower the danger of bromocriptine’s hypoprolactemic impact. Domperidone’s effect on Gl function may be inhibited by antimuscarinics and opioid analgesics. Domperidone should be used with caution when combined with MAO (monoamine oxidase) inhibitors.

Contraindications

Domin 10 mg is contraindicated in individuals who have a history of hypersensitivity to the medication, as well as in newborns. Domin 10 mg should not be taken if there is a risk of gastrointestinal stimulation, such as gastrointestinal bleeding, mechanical blockage, or perforation. It is also not recommended for people who have a prolactin-releasing pituitary tumor (prolactinoma).

Side Effects of Domin 10 mg Tablet

Domin 10 mg has the potential to cause hyperprolactinemia (1.3 percent ). This can cause galactorrhea, breast enlargement, discomfort, and a decrease in libido. During domperidone therapy, dry mouth (1%), thirst, headache (1.2%), anxiety, sleepiness (0.4%), diarrhea (0.2%), skin rash, and itching (0.1%) are possible side effects. Clinical investigations show that extrapyramidal responses occur in 0.05 percent of individuals.

Pregnancy & Lactation

Domin 10 mg tablet’s safety has not been established, and it is thus not recommended during pregnancy. Teratogenicity in the fetus has not been shown in animal investigations. Domperidone can cause galactorrhea and enhance postpartum lactation. It is released in breast milk, but in such tiny amounts that it is not considered hazardous.

Precautions & Warnings

Domin 10 mg should be used with extreme caution in children due to an increased risk of extrapyramidal effects in young children due to an inadequately formed blood-brain barrier. Domperidone, because it is extensively metabolized in the liver, should be taken with care in patients with hepatic impairment.

Therapeutic Class

Motility Stimulants, Motility stimulants/Dopamine antagonists, Prokinetic drugs

Storage Conditions

Store below 30°C, away from light and moisture. Keep out of the reach of youngsters.

Generic of Domin 10 mg Tablet

Domperidone Maleate