Docopa 100 ML


Docopa 100 ML


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Indications of Docopa 100 ml

Doxophylline is used to treat asthma, COPD, and bronchospasm.

Pharmaceutical Name of Docopa 100 ml

Aristopharma Ltd.


The drug doxophylline is a brand-new bronchodilator. The inclusion of a dioxolane group in position 7 distinguishes it from Theophylline structurally. Doxophylline relaxes bronchial smooth muscle by inhibiting phosphodiesterase 4 specifically. Doxophylline, unlike Theophylline, appears to have a lower affinity for adenosine A1 and A2 receptors, which could account for the drug’s improved safety profile. Doxophylline has been shown to suppress platelet-activating factor (PAF) production as well as the creation of leukotrienes.

Dosage and Administration

Elderly: 200 mg tablet two or three times daily.

Adults: 400 mg tablet two or three times daily or as prescribed by the physician.


>12 years of age: 10 ml syrup or 200 mg tablet two or three times daily.

6-12 years of age: 6-9 mg/kg body weight two times daily, i.e. if body weight is 10 kg, 3 ml (60 mg) two times daily or as prescribed by the physician.

If the required daily dose of Doxophylline is 400 mg then the Doxophylline SR tablet is to be taken once daily or as prescribed by the physician

Interaction of Docopa 100 ml

Other xanthine derivatives should not be taken simultaneously with doxophylline. Xanthines have been shown to have toxic synergism with ephedrine. Concomitant therapy with troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol, and anti-flu vaccine, as with other xanthines, may reduce xanthine hepatic clearance, resulting in an increase in blood levels. There has been no indication of a link between Doxophylline serum concentrations and harmful occurrences.


In acute myocardial infarction, doxophylline is contraindicated. Individuals with hypotension, nursing women, and patients who have exhibited allergy to its components are also advised against using it.

Side Effects of Docopa 100 ml

Doxophylline rarely causes serious side effects, however possible side effects are similar for taking excess amounts of caffeine. These include nausea, vomiting, headache, upset stomach, and heartburn.

Pregnancy & Lactation

Animal reproduction studies show that doxophylline has no effect on reproduction capacity or causes fetal harm when given to pregnant animals. However, because there is minimal experience with xanthines during pregnancy in humans, they should only be given to pregnant women if absolutely necessary. Doxophylline should not be taken by breastfeeding mothers.

Precautions & Warnings

A number of known variables influence the half-life of xanthine derivatives. Patients with liver illness, congestive heart failure, and those on certain other treatments such as erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propranolol, and the anti-flu vaccine may experience a delay. In these circumstances, a lower Doxophylline dose may be required. Smoking, phenytoin, and other anticonvulsants may cause an increase in clearance and a shorter mean half-life. In these circumstances, greater Doxophylline doses may be required.

Therapeutic Class

Bronchodilator, Methyl xanthine derivatives

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children. Doxophylline should be used only on the prescription of a specialist physician.

Generic of Docopa 100 ml