Generic

Fexofenadine Hydrochloride

Indications

Fexofenadine Hydrochloride is used to treat the symptoms of seasonal allergic rhinitis in both adults and children. It’s also used to treat the cutaneous signs of chronic idiopathic urticaria that aren’t too severe.

Pharmacology

Fexofenadine Hydrochloride is an antihistamine that works by blocking peripheral H1 receptors. After oral administration, it is rapidly absorbed and reaches maximal plasma concentration in 2-3 hours. It doesn’t appear to be able to pass through the blood-brain barrier.

Dosage & Administration

Seasonal Allergic Rhinitis-

Adults and children 12 years and older:

Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily

In case of impaired renal function: 60 mg once daily

Children from 6 to 11 years:

Tablet: 30 mg twice daily or 60 mg once daily

In case of impaired renal function: 30 mg once daily

Children from 2 to 11 years

Suspension: 30 mg or 5 ml twice daily

In case of impaired renal function: 30 mg or 5 ml once daily

Chronic Idiopathic Urticaria-

Adults and children 12 years and older:

Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily

In case of impaired renal function: 60 mg once daily

Children from 6 to 11 years:

Tablet: 30 mg twice daily or 60 mg once daily

In case of impaired renal function: 30 mg once daily

Children from 6 months to less than 2 years:

Suspension: 15 mg or 2.5 ml (1/2 tsp) twice daily

In case of impaired renal function: 15 mg or 2.5 ml (1/2 tsp) once daily

Children from 2 to 11 years:

Suspension: 30 mg or 5 ml (1 tsp) twice daily

In case of impaired renal function: 30 mg or 5 ml (1 tsp) once daily

Interaction

Plasma concentration of Dinafex have been increased when given with erythromycin or ketoconazole. Aluminium and magnesium hydroxide containing antacid reduces the absorption of Dinafex.

Contraindications

Contraindicated in patients with known hypersensitivity to Dinafex or any of its ingredients.

Side Effects

Common side effects are headache, fatigue, drowsiness, nausea, dry mouth and gastrointestinal disturbances.

Pregnancy & Lactation

Dinafex is classified as pregnancy category C by the US Food and Drug Administration. So, unless the potential benefits to the other outweigh the potential hazards to the fetus, Fexofenadine Hydrochloride should be avoided during pregnancy and lactation.

Precautions & Warnings

Caution should be exercised in elderly patient and patient with decreased renal function.

Therapeutic Class

Non-sedating antihistamines

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Pharmaceutical Name

SK-F Pharmaceuticals Limited