Diflu 50MG


Diflu 50MG


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It is indicated in the treatment of vaginal candidiasis, oropharyngeal & oesophageal candidiasis, candidal urinary tract infection, peritonitis, systemic candidiasis and cryptococcal meningitis.

Dosage & Administration

The daily dose of DIFLU should be based on the nature and severity of the fungal infection. Most cases of the fungal infections require multiple dose therapy. Treatment should be continued until clinical parameters of laboratory tests indicate that active fungal infection has subsided. An inadequate period of treatment may lead to recurrence of active infection. Immunocompromised patients usually require maintenance therapy to prevent relapse.


It is contraindicated to patients hypersensitive to this drug and in advanced liver disease and in nursing mother.

Warning & Precautions

Caution should be taken in renal impairment, pregnancy and breast-feeding and the raised liver enzymes.

Side effects

Therapy with Fluconazole is well tolerated. The common adverse effects are nausea. abdominal pain, vomiting, diarrhoea, headache and skin rash.

Drug interaction

Rifampicin reduces plasma concentration of Fluconazole. Fluconazole enhances the effect of nicoumalone, warfarin and phenytoin. It also increases the plasma concentration of sulphonylureas & theophlline.

Use in special groups

Use in pregnancy :Fluconazole should be used in pregnancy only if the potential benefit justifies the possible risk to the foetus.
Use in lactation :Fluconazole is secreted in human milk at concentrations similar to plasma. Therefore, the use of Flouconazole in nursing mother is not recommended.