Indications of Dicot 10 Cream

Econazole Nitrate & Triamcinolone Acetonide are indicated for the treatment of:

1. Eczematous Mycoses
2. Psoriasis
3. Tinea Pedis (Athlete’s foot)
4. Tinea Corporis (Ringworm)
5. Tinea Cruris (Jock itch)
6. Inflammatory Intertrigo
7. Diaper Dermatitis

Onychomycoses- for the treatment of onychomycoses, local therapy with Econazole/Triamcinolone cream, combined with an oral antimycotic, is recommended.

Pharmacology of Dicot 10 Cream

Econazole Nitrate: Econazole modifies the permeability of cell wall membrane in fungi; may interfere with RNA and protein synthesis, and lipid metabolism.

Triamcinolone has mainly glucocorticoid activity. It suppresses the migration of polymorphonuclear leukocytes and reduces capillary permeability thereby decreasing inflammation.

Dosage & Administration of Dicot 10 Cream

Adults: This cream should be applied sparingly to the skin lesion no more than 2 times daily, preferably once in the morning and once in the evening. This cream should not be applied with an occlusive dressing or too large areas of skin on the body. The duration of treatment with this cream should continue until the inflammatory symptoms subside but not longer than 2 weeks; after 2 weeks of therapy with this cream, continue therapy as needed with a preparation containing econazole or econazole nitrate alone.

Pediatric Use: Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing’s syndrome than mature patients because of a larger skin surface area to body weight. Caution should be exercised.

Interaction of Dicot 10 Cream

Econazole is an oral anticoagulant that is metabolized by the CYP3A4/2C9 enzyme. Triamcinolone reduces the number of salicylates in the blood. NSAIDs increase the risk of Gl bleeding and ulceration. Antagonized the antidiabetic’s blood glucose-lowering effects. Amphotericin B, beta-blockers, potassium-depleting diuretics, and theophylline all increase the risk of hyperkalemia. With ciclosporin, carbamazepine, phenytoin, barbiturate, and rifampicin, triamcinolone clearance is increased.

Contraindications

Individuals who have proven allergy to any of the components in this cream are contraindicated.

This Cream, like any other corticosteroid-containing dermatological preparation, is contraindicated in certain skin diseases, such as tuberculosis, varicella, herpes simplex, or other viral skin infections, or new vaccination sites.

Decubitus ulcers are skin diseases caused by viruses, bacteria, or fungi (e.g. tuberculosis of the skin, syphilis of the skin, herpes simplex, herpes zoster, chickenpox).

Rosacea and rosacea-like dermatitis are two types of rosacea.

Side Effects of Dicot 10 Cream

Transient local mild discomfort, itching, and redness may occur following application on a rare occasions. Econazole has low allergenicity and is well tolerated by even sensitive skin. Adrenal suppression can occur while using long-term continuous topical steroid treatment, especially in babies and toddlers, or when using occlusive dressings. It’s important to keep in mind that an infant’s napkin might serve as an occlusive dressing.

Pregnancy & Lactation

Pregnancy: Triamcinolone Acetonide, not Econazole, penetrates the placenta, therefore topical corticosteroids during pregnancy might induce fetal development problems. The applicability of this discovery to humans has yet to be determined. Topical steroids in big doses or for lengthy periods of time should not be used during pregnancy.

Lactation: A tiny quantity of econazole and, to a lesser degree, Triamcinolone is secreted in breast milk. As a result, this cream should not be given to a nursing woman, or if it is, lactation should be stopped during therapy.

Precautions & Warnings

Only for external usage. This cream is not intended for use on the eyes or in the mouth. If a response that suggests hypersensitivity or chemical irritation occurs, the drug should be stopped immediately.

Corticosteroids applied to the skin can be absorbed in large enough quantities to have systemic effects, such as adrenal suppression. Various variables, including as treatment across a wide skin surface area, application to injured skin, administration beneath occlusive skin dressings, and prolonged therapy duration, may enhance systemic absorption.

Skin thinning and atrophy, striae, telangiectasis, and purpura have all been linked to topical corticosteroids.

Youngsters: When treating children, extra vigilance is necessary. The nature of a child’s skin, as well as the greater skin surface area relative to body weight, may contribute to higher corticosteroid absorption via the skin. This cream should only be used on tiny areas and for brief periods of time in youngsters (less than 2 weeks) (less than 10 percent of body surface area).

Therapeutic Class

Triamcinolone & Combined preparations.

Storage Conditions

Store away from light in a cold (below 30°C) and dry location. Keep out of children’s reach.

Pharmaceutical Name of Dicot 10 Cream

Drug International Ltd

Generic of Dicot 10 Cream

Econazole Nitrate + Triamcinolone Acetonide