Description
Indications of Diclofen 25
Rheumatology includes inflammatory and degenerative rheumatism, polyarthritis, ankylosing spondylarthritis, osteoarthritis, spondylarthritis, acute gout, and peri-articular rheumatic diseases.
Sprains, bruises, dislocations, fractures, soft-tissue injuries, and surgical treatments are all examples of surgery and traumatology.
Primary dysmenorrhoea, episiotomy, adnexitis, endometritis, parametritis, salpingitis, and mastitis are all conditions seen in obstetrics and gynecology.
Pre-operative medicine for the prevention of pain, inflammation, and edema in otorhinolaryngology.
Post-operative and post-traumatic discomfort, inflammation, and edema are common in dentistry.
Other indications include pain relief and the treatment of inflammation and edema in individuals who have had urogenital, renal, or biliary colic.
Pharmaceutical Name of Diclofen 25
Opsonin Pharma Limited.
Pharmacology
Diclofenac Sodium is an anti-rheumatic, anti-inflammatory, analgesic, and antipyretic non-steroidal anti-inflammatory medication (NSAID). It also possesses uricosuric properties. Diclofenac works by blocking prostaglandin production, which is a key factor in the development of inflammation, discomfort, and fever. When taken with or after a meal, diclofenac is swiftly and fully absorbed from the gastrointestinal system. After consumption, peak plasma concentrations are attained in an average of 2 hours. It is 99.7% bound to plasma proteins at therapeutic doses. Diclofenac is metabolized in the liver and passes through a first-pass process.
Dosage & Administration
Diclofenac FC Tablet: Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food. The dose should be reduced in long-term use.
Diclofenac SR Tablet:
- Adult: 1 tablet daily, taken whole with liquid, preferably at meal times. If necessary, the daily dose can be increased to 150 mg by supplementation with conventional tablets.
- Children: 1-3 mg of diclofenac/kg body wt. daily in divided doses.
- Elderly patients: In elderly or debilitated patients, the lowest effective dosage is recommended, although the pharmacokinetics of diclofenac sodium is not impaired to any clinically relevant extent in elderly patients.
Diclofenac Dispersible Tablet:
- Adults: The recommended daily dosage is 2-3 tablets and the maximum daily dose is 150 mg. In milder cases, 2 tablets of Diclofenac DT per day are sufficient. Diclofenac DT should preferably be taken before meals.
- Children: Diclofenac is not recommended in children for other indications except juvenile rheumatoid arthritis where the recommended dose is 1-3 mg/kg body weight. Diclofenac DT is to be dropped into a half-glass of water and the liquid is to be stirred to aid dispersion before swallowing. There is no information on the use of Diclofenac DT for more than 03 months.
Diclofenac TR Capsule: One capsule daily. Diclofenac TR should be taken preferably after mealtimes.
Diclofenac Suppository: For adults: 50 mg suppository 2-3 times daily. The maximum daily dose is 150 mg.
Diclofenac injection: For adults the usual dose is 1 ampoule daily. In serious cases, this dose may be increased up to 2 ampoules daily.
Diclofenac Gel: For external use only. Depending on the size of the area to be treated, 2-4 g of Diclofenac gel should be applied to the skin 3-4 times daily. To the affected area gel should be rubbed in lightly. This gel may also be given in addition to further treatment with other dosage forms of Diclofenac.
Interaction of Diclofen 25
Diuretics can be inhibited by a variety of non-steroidal anti-inflammatory drugs. Concomitant therapy with potassium-sparing diuretics may result in elevated blood potassium levels, necessitating regular monitoring. Patients using Diclofenac while simultaneously taking digoxin, methotrexate, cyclosporine, or lithium should be monitored for the development of these medicines’ particular side effects. Other systemic nonsteroidal anti-inflammatory drugs or glucocorticoids taken at the same time may increase the risk of adverse effects, such as gastrointestinal bleeding.
Contraindications
Patients who are allergic to any of the goods’ ingredients should avoid using it. Peptic ulcer, hypersensitivity to Diclofenac, as well as other non-steroid anti-inflammatory agents. Diclofenac is also contra-indicated in asthmatic patients who have had an attack of asthma, urticaria, or acute rhinitis triggered by acetylsalicylic acid or other drugs that inhibit prostaglandin synthetase. Under occlusive airtight dressings, this Gel should not be utilized.
Side Effects of Diclofen 25
Diclofenac Sodium is well tolerated by most people. Mild, infrequent, and transitory side effects are common. Patients may have epigastric discomfort, eructation, nausea, and diarrhea, as well as dizziness or headache, during the commencement of therapy. In most cases, these side effects are minor. There have also been reports of peripheral edema and skin responses such as rash and dermatitis. Diclofenac Sodium Gel can produce skin irritation, reddening, and a rash on the affected area.
Pregnancy & Lactation
Diclofenac should only be used if absolutely necessary during pregnancy. The smallest dose that is effective should be utilized. These medications are not advised to be taken during the first trimester of pregnancy. Diclofenac Sodium Gel is not suggested during pregnancy due to a lack of clinical evidence. Although a trace amount of Diclofenac may be found in breast milk, no adverse effects on the child are predicted.
Precautions & Warnings
In rare cases, people using Diclofenac may develop peptic ulcers or have gastrointestinal bleeding. Patients in their advanced years should be closely monitored. Diclofenac Sodium Gel should not be applied to the eyes or mucous membranes, and the hands should be thoroughly cleaned after application. It should not be consumed by mouth.
Therapeutic Class
Storage Conditions
Store in a cold, dry, and light-protected location. Keep it below 30°C. Keep out of children’s reach.
