Indications of Dextromethorphan 100ml Syrup

Dextromethorphan is used to relieve dry cough caused by a cold, flu or other conditions.

Pharmacology of Dextromethorphan 100ml Syrup

Dextromethorphan works directly on the cough center in the medulla of the brain to suppress the cough reflex. Dextromethorphan binds to multiple brain areas with great affinity, including the medullary cough center. This substance works as a non-competitive channel blocker and functions as an NMDA receptor antagonist. It’s a common antitussive that’s also used to investigate the role of glutamate receptors in neurotoxicity.

Dextromethorphan 100ml Syrup Dosage & Administration

Tomephen is an orally administered syrup.

Adults (>12 years of age): 10-20 mg (1-2 teaspoonful) every 4 hours, or 30 mg (3 teaspoonful) every 6-8 hours. Do not exceed 120 mg (12 teaspoonful) in 24 hours.

Children

• 6 to 12 years of age: 5-10 mg (1/2-1 teaspoonful) every 4 hours, or 15 mg (11/2 teaspoonful) every 6-8 hours. Do not exceed 60 mg (6 teaspoonful) in 24 hours.
• 2 to 6 years of age: 2.5-5 mg (1/4-1/2 teaspoonful) every 4 hours, or 7.5 mg (3/4 teaspoonful) every 6-8 hours. Do not exceed 30 mg (3 teaspoonful) in 24 hours.
• <2 years of age: Use only as directed by the physician.

Interaction

Amiodarone, Fluoexetine, Quinidine, CNS depressants, and Monoamine oxidase (MAO) inhibitors should be used with caution when used together with Dextromethorphan.

Contraindications

Hypersensitivity to any component, including dextromethorphan.

Side Effects

Adverse effects with Dextromethorphan appear to be rare and may include dizziness and gastrointestinal disturbances.

Pregnancy & Lactation

Pregnancy: Adequate and well-controlled studies in human have not been done. However, Dextromethorphan has not been reported to cause birth defects.

Lactation: It is not known whether dextromethorphan passes into breast milk. However, Dextromethorphan has not been reported to cause problems in nursing babies.

Precautions & Warnings

Do not use Dextromethorphan to control a cough that is associated with smoking, asthma, or emphysema, or a cough that is productive (produces sputum or phlegm).

Therapeutic Class

Cough suppressant

Storage Conditions

Temperatures should be kept between 15 and 30 degrees Celsius.

Pharmaceutical Name

Beximco Pharmaceuticals Ltd

Generic

Dextromethorphan Hydrobromide