Indications of Dexagen C

Eye: Acute purulent conjunctivitis, new corneal inflammation, and corneal ulceration are all indications for this combination. Another usage for the drug is in the treatment of corneal injuries caused by chemical radiation and thermal burns, as well as foreign body penetration and post-herpetic keratitis. Corticosteroids are used in conjunction with this medication to treat inflammation of the eye that responds to corticosteroids in the presence of germs.

An otitis externa, medial, or chronic otitis inflamed with pus is treated with this combination.

Pharmaceutical Name of Dexagen C

Pharmacology

It’s a glucocorticoid called dexamethasone. In addition, it contains anti-inflammatory and anti-allergic properties. Inflammatory disorders of the eye’s anterior region are treated topically with this drug. When taken orally, Dexamethasone is rapidly absorbed, with a half-life of approximately 190 minutes. After topical treatment to the skin and eyes, there may be sufficient absorption to create systemic effects on the body.

In addition to being an antibiotic that works on both Gram negative and Gram positive bacteria, chloramphenicol is also an antifungal that has a broad spectrum of activity. Chloramphenicol inhibits bacterial protein production by attaching to bacterial ribosomes.

Administration & Dosage

Eye:

• Bacterial Conjunctivitis: The recommended dosage regimen for the treatment of bacterial conjunctivitis is 1 to 2 drops instilled into the conjunctival sac (s) every 2 hours for 2 days and 1 or 2 drops every 4 hours for the next 5(five days) while awake.
• Corneal Ulcers: The recommended dosage regimen for the treatment of comeal ulcer is 2 drops in the affected eye (s) every 15 minutes for the first 6 hours then 2 drops into the affected eye(s) every 30 minutes for the remainder of first day. On the second day, instill 2 drops in the affected eye (s) hourly. On the 3 to 14 days, place 2 drops in the affected eye (s) every 4 hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occurred.

Ear: For all infections, 2 to 3 drops every 2 to 3 hours initially. Frequency should be decreased gradually as warranted by improvement in clinical signs. Care should be taken not to discontinue therapy prematurely.

Interaction of Dexagen C

There may be an increase in the effects of Chloramphenicol if it is absorbed from the eye whilst taking anticoagulants, such as warfarin. Phenobarbital will inhibit the action of Chloramphenicol. When phenytoin, phenobarbitone, ephedrine, and rifampicin are used concurrently with Dexamethasone, its therapeutic efficacy may be diminished.

Contraindications

Infections of the eye, such as epithelial herpes simplex cornealis, fungal, viral, tuberculous, and others, and glaucoma, are contraindicated with this combination. Chloramphenicol induced myelosuppression. Toxic reaction to Chlorampheniclol or to any of the other components in the preparations (such as Dexamethasone Phosphate).

Side Effects of Dexagen C

Other reported responses include stinging, redness, itching, conjunctivitis, foreign-body sensation (photophobia), impaired vision, dryness and eye pain when using Chloramphenicol. Chloramphenicol may cause allergic sensitization when used locally. High intraocular pressure with possible glaucoma development, optic nerve damage and posterior subcapsular cataract formation are some of the symptoms of hypertension.

Pregnancy & Lactation

There are no satisfactory and well-controlled considers in pregnant ladies. This medicate ought to be utilized amid pregnancy as it were on the off chance that the potential advantage legitimizes the potential hazard to the baby. Caution ought to be worked out when Chloramphenicol and Dexamethasone ophthalmic arrangement is managed to a nursing mother.

Precautions & Warnings

The plausibility of diligent contagious diseases of the cornea ought to be considered after drawn out corticosteroid dosing. Delayed utilize of steroids containing items may result in back subcapsular cataract arrangement and glaucoma with optic nerve harm. Intraocular weight checking is required. Drawn out utilize of anti-microbials may result within the excess of non-susceptible living beings, counting parasites. In case unused contaminations show up amid treatment, the medicate ought to be ceased and elective treatment ought to be foundations.

Therapeutic Class

Ophthalmic steroid – antibiotic combined preparations

Storage Conditions