Deflux 10MG

100410014300601

Deflux 10MG

3.50৳ 

Stock Status:

In Stock

  • *Upload Prescription

    • (max file size 80 MB)

Description

Generic

Domperidone Maleate

 

Indications

A complex of dyspeptic symptoms, generally associated with delayed gastric emptying, gastroesophageal reflux, and esophagitis:

  • Fullness, abdominal distention, upper abdominal pain
  • Belching, flatulence, early satiety
  • Nausea and vomiting
  • Heartburn with or without gastric reflux in the mouth
  • Dyspepsia non-ulcer
  • Acute, functional, organic, infectious nausea and vomiting, of dietary origin or induced by radiotherapy or pharmacotherapy or induced by migraine.
  • Parkinson’s disease: nausea and vomiting caused by dopamine receptor agonists.
  • Radiology Research: Accelerating Barium Transport in Follow-up Radiology Research.

 

Pharmacology

Domperidone is a dopamine antagonist that mainly blocks dopamine receptors located in the chemoreceptor activation zone (CTZ) and stomach. Its gastrointestinal motility is based on its blocking effect on dopamine receptors that affect gastrointestinal motility. Due to its weak permeability to the blood-brain barrier, domperidone has almost no effect on dopamine receptors in the brain, thus eliminating mental and neurological side effects. Domperidone restores the normal movement and tension of the upper gastrointestinal tract, promotes gastric emptying, improves gastric antrum and duodenal peristalsis, and regulates pyloric contraction. Domperidone also increases esophageal motility and reduces esophageal sphincter pressure, thereby preventing the reflux of stomach contents.

 

Dosage & Administration

Deflux should be taken between 15 and 30 minutes before meals and, if necessary, before bedtime. The commonly recommended oral doses of

domperidone are as follows:

adults: 1020 mg (12 tablets or 1020 ml suspension), once every 68 hours a day. The maximum dose of domperidone is 80 mg per day.

children: 24 ml suspension/10 kg body weight or 0.40.8 ml pediatric drops/10 kg body weight every 68 hours every day.

Indigestion symptoms:

Adults: 1020 mg (12 tablets or 1020 ml suspension), once every 68 hours a day.

children: 0.20.4 mg/kg (24 ml suspension/10 kg or 0.40.8 ml pediatric drops/10 kg) weight every 68 hours per day.

In acute and subacute situations (mainly acute nausea and vomiting):

Adults: 20 mg (2 tablets or 20 ml suspension), every 68 hours per day

Children: 0.20.4 mg/kg (24 ml suspension) /10 kg or 0.40.8 ml pediatric drops/10 kg) body weight, once every 68 hours a day. (In acute nausea and vomiting, the maximum treatment period is 12 weeks).

Rectal suppositories:

Adults (including the elderly): 3060 mg every 48 hours.

Children: The maximum daily rectal dose for children weighing 10 to 25 kg is 30 mg. If necessary, it can be taken in divided doses throughout the day.

The maximum treatment period is 12 weeks.

 

Interaction

Deflux can reduce the risk of bromocriptine causing hypoprolactin. The effect of domperidone on GI function can be antagonized by antimuscarinic drugs and opioid analgesics. Caution should be exercised when domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.

 

Contraindications

Deflux is contraindicated in patients and newborns who are known to be allergic to this drug. Domperidone should not be used when gastrointestinal irritation could be dangerous, ie gastrointestinal bleeding, mechanical obstruction or perforation. Prolactin-releasing pituitary tumors (prolactinomas) are also contraindicated.

 

Side Effects

Domperidone can cause hyperprolactinemia (1.3%). This can cause galactorrhea, breast enlargement, pain, and decreased libido. Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), rash and itching ( 0.1%). In clinical studies, 0.05% of patients had extrapyramidal reactions.

 

Pregnancy & Lactation

The safety of domperidone has not been proven, so its use during pregnancy is not recommended. Animal studies have not shown teratogenic effects on the fetus. Domperidone can cause galactorrhea and improve postpartum lactation. It is secreted in breast milk, but the amount is very small and not enough to be considered harmful.

 

Precautions & Warnings

The safety of Deflux has not been proven, so its use during pregnancy is not recommended. Animal studies have not shown teratogenic effects on the fetus. Domperidone can cause galactorrhea and improve postpartum lactation. It is secreted in breast milk, but the amount is very small and not enough to be considered harmful.

 

Therapeutic Class

Sports stimulants, sports stimulants/dopamine antagonists, prokinetics

 

Storage Conditions

Store below 30 ° C protected from light and moisture. Keep out of the reach of children.

 

Pharmaceutical Name

Beximco Pharmaceuticals Ltd.