Deflux 100ML

100410602000601

Deflux 100ML

38.00৳ 

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In Stock

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Description

Indications of Deflux 100 ml

  • Delayed stomach emptying, gastroesophageal reflux, and esophagitis are all symptoms of the dyspeptic symptom complex.
  • Upper abdominal pain, the feeling of abdominal distension, and epigastric fullness
  • Eructation, flatulence, and early satiety are all symptoms of early satiety.
  • Vomiting and nausea
  • Regurgitation of stomach contents into the mouth, with or without heartburn
  • Dyspepsia without ulcers
  • Acute nausea and vomiting of functional, organic, infectious, or dietetic origin, as well as nausea and vomiting generated by radiotherapy or pharmacological therapy, and nausea and vomiting induced in migraine.

Pharmaceutical Name of Deflux 100 ml

Beximco Pharmaceuticals Ltd.

Pharmacology

Domperidone is a dopamine agonist that works by blocking dopamine receptors in the chemoreceptor trigger Zone (CTZ) in the stomach. Its gastroprokinetic function is based on the inhibition of dopamine receptors in the gastrointestinal tract, which impacts motility. Domperidone has essentially no effect on dopaminergic receptors in the brain due to its poor penetration across the blood-brain barrier, hence avoiding psychotropic and neurologic adverse effects. Domperidone restores normal upper gastrointestinal motility and tone, aids stomach emptying, improves antral and duodenal peristalsis, and modulates pylorus contraction. Domperidone.

Dosage & Administration

Domperidone should be taken 15-30 minutes before meals and, if necessary, before retiring.

The usual recommended oral dose of Domperidone is as follows:

  • Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
  • Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight, every 6-8 hours daily.

In dyspeptic symptoms:

  • Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily.
  • Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml pediatric drops/10 kg) body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

  • Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
  • Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml pediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

By rectum in suppositories:

  • Adults (including elderly): 30-60 mg every 4-8 hours.
  • Children: The maximum daily dose rectally in children is 30 mg for those weighing 10 to 25 kg. The dose may be divided throughout the day if necessary.
  • The maximum period of treatment is 12 weeks.

Interaction of Deflux 100 ml

Bromocriptine’s hypoprolactemic impact may be reduced by domperidone. Antimuscarinics and opioid analgesics may counteract Domperidone’s effect on Gl function. When domperidone is used with MAO (monoamine oxidase) inhibitors, caution should be exercised.

Contraindications

Domperidone is a dopamine agonist that works by blocking dopamine receptors in the chemoreceptor trigger Zone (CTZ) in the stomach. Its gastroprokinetic function is based on the inhibition of dopamine receptors in the gastrointestinal tract, which impacts motility. Domperidone has essentially no effect on dopaminergic receptors in the brain due to its poor penetration across the blood-brain barrier, hence avoiding psychotropic and neurologic adverse effects. Domperidone restores normal upper gastrointestinal motility and tone, aids stomach emptying, improves antral and duodenal peristalsis, and modulates pylorus contraction.

Side Effects of Deflux 100 ml

Domperidone may produce hyperprolactinemia (1.3%).This may result in galactorrhea, breast enlargement, soreness, and reduced libido. Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash, and itching (0.1%) may occur during treatment with domperidone. Extra-pyramidal reactions are seen in 0.05% of patients in clinical studies.

Pregnancy & Lactation

The safety of domperidone has not been proven and it is therefore not recommended during pregnancy. Animal studies have not demonstrated the teratogenic effect on the fetus. Domperidone may precipitate galactorrhea and improve post-natal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.

Precautions & Warnings

Domperidone should be used with absolute caution in the case of children because there may be an increased risk of extrapyramidal reactions in young children because of an incompletely developed blood-brain barrier. Since domperidone is highly metabolized in the liver, it should be used with caution in patients with hepatic impairment.

Therapeutic Class

Motility Stimulants, Motility stimulants/Dopamine antagonists, Prokinetic drugs

Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children’s reach.

Generic of Deflux 100 ml

Domperidone Maleate