Daomin 500 MG


Daomin 500 MG


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Metformin Hydrochloride



Treatment of sort 2 diabetes mellitus, especially in overweight patients when dietary administration and work out alone does not result in satisfactory glycaemic control.

  • In adults: Metformin may be utilized as monotherapy or in combination with other verbal antidiabetic specialists or with insulin.
  • In children from 10 years of age and youths: Metformin may be utilized as monotherapy or in combination with insulin. A diminishment of diabetic complications has been appeared in overweight sort 2 diabetic grown-up patients treated with metformin as first-line treatment after eat less disappointment.


Metformin may be a biguanide sort verbal antihyperglycemic medicate utilized within the administration of sort 2 diabetes. It brings down both basal and postprandial plasma glucose. Its instrument of activity is diverse from those of sulfonylureas and it does not deliver hypoglycemia. Metformin diminishes hepatic glucose generation, diminishes intestinal retention of glucose and makes strides affront affectability by an increment in fringe glucose take-up and utilization.


Dosage and Administration

Metformin prompt discharge tablet: Measurement of Metformin Hydrochloride must be individualized on the premise of both adequacy and resistancewhereas not surpassing the most extreme suggested every day doses.

Adult: The regular beginning dosage of Metformin is 500 mg twice a day or 850 mg once a day, given  with dinnersMeasurement increments ought to be made in increases of 500 mg week after week or 850  mg each 2 weeks, up to a add up to of 2000 mg per day, given in partitioned dosages. For those patients  requiring extra glycemic control, Glucomin may be given to a most extreme every day measurements of  2550 mg per day. Measurements over 2000 mg may be superior endured given three times a day with  meals.

Children: The regular beginning measurements of Metformin is 500 mg twice a day, given  with   dinnersDose increments ought to be made in increases of 500 mg week after week up to a most   extreme of 2000 mg per day, given in separated dosages.
Metformin expanded discharge tablet: Swallow Metformin XR tablet entirety and never pulverize, cut or chew.
Adult: The regular beginning dosage of Metformin XR is 500 mg once day by day with the evening  supperDosage ought to be expanded in increases of 500 mg week after week, up to a most  extreme of  2000 mg once day by day with the evening feaston the other hand expanded to 1000 mg  twice day by  day taken with feastUnderstanding accepting Metformin quick discharge tablet may  be exchanged to  Metformin amplified discharge tablet up to a greatest suggested day by day dose.
Children: Metformin expanded discharge tablet has not been examined in children.
Renal disabled quietDon’t utilize Metformin in patients with eGFR underneath 30 mL/min/1.73 m2. Asses  risk/benefit of tallying in case eGFR falls underneath 45 mL/min/1.73 m2.


Co-administration with Carbonic anhydrase (Topiramate, Zonisamide) may increment chance of lactic acidosis. Drugs (Ranolazine, Dolutegravir, Cimetidine) that diminish Metformin clearance may increment the aggregation of Metformin. Liquor can potentiate the impact of Metformin on lactate digestion system.



  • Extreme touchiness to the dynamic substance or to any of the excipients.
  • Any sort of intense metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).
  • Severe renal disappointment (GFR <30 mL/min).
  • Acute conditions with the potential to modify renal work such as: drying outextreme disease, shock.
  • Acute or inveterate malady, which may cause tissue hypoxia such as: cardiac or respiratory disappointmentlater myocardial dead tissuestun, Hepatic insufciency, intense liquor inebriationliquor addiction.


Side Effects

  • Blood and lymphatic framework disarranges: Not known: Hemolytic anemia
  • Metabolism and nourishment disarranges: Exceptionally uncommon: Lactic acidosis. Diminish of vitamin B12 assimilation with a diminish of serum levels amid long-term utilize of metformin. Thought of such etiology is suggested in case a quiet presents with megaloblastic iron deficiency. Cases of fringe neuropathy in patients with vitamin B12 insufficiency have been detailed in post-marketing encounter (recurrence not known)
  • Nervous framework clutters: Common: Taste unsettling influence. Not known: Encephalopathy
  • Gastrointestinal disarranges: Exceptionally common: Gastrointestinal disarranges, such as queasinessheavingthe runsstomach torment, and misfortune of craving. These undesirable impacts happen most as often as possible amid the start of treatment and resolve suddenly in most cases. To avoid them, it is prescribed that metformin be taken in 2 or 3 day by day dosages amid or after suppers. A moderate increment of the dosage may too progress gastrointestinal tolerability.
  • Hepatobiliary clutters: Exceptionally uncommonSeparated reports of liver work test variations from the norm or hepatitis settling upon metformin discontinuation.
  • Skin and subcutaneous tissue clutters: Exceptionally uncommon: Skin responses, such as erythema, pruritus, urticaria.


Pregnancy & Lactation

Pregnancy: Uncontrolled diabetes amid pregnancy (gestational or changeless) is related with an expanded hazard of intrinsic anomalies and perinatal mortality. When the understanding plans to gotten to be pregnant and amid pregnancy, it is suggested that diabetes isn’t treated with metformin but insulin be utilized to preserve blood glucose levels as near to typical as conceivable, to diminish the chance of deformities of the embryo.

Breastfeeding: Metformin is excreted into human breast drain. No antagonistic efects were watched in breastfed newborns/infants. In any case, as as it were restricted information are accessible, breastfeeding isn’t prescribed amid metformin treatment. A choice on whether to suspend breastfeeding ought to be made, taking under consideration the advantage of breastfeeding and the potential chance to unfavorable impacts on the child.


Precautions & Warnings

Metformin Hydrochloride is known to be considerably excreted by the kidney and the chance of Metformin amassing and lactic acidosis increments with the degree of impedance of renal work. Metformin may lower vitamin B12 level. It too increments hazard of hypoglycemia when utilize in combination with affront or affront secretagogue.


Therapeutic Class



Storage Conditions

Keep below 30°C temperature, secured from light & dampness. Keep out of the reach of children.


Pharmaceutical Name

ACME Laboratories Ltd.