Creston 10MG


Creston 10MG


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  • Heterozygous Hypercholesterolemia is treated with rosuvastatin (Familial and Non familial)
  • Hypercholesterolemia Homozygous (Familial)
  • Dyslipidemia (Mixed) (Fredrickson Type IIa and IIb)
  • Primary cardiovascular disease prevention



Rosuvastatin could be a particular and competitive inhibitor of HMG-CoA reductase, the rate-limiting protein that changes over 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a forerunner of cholesterol. Rosuvastatin produces its lipid-modifying impacts in two ways. To begin with, it increments the number of hepatic LDL receptors on the cell surface to improve take-up and catabolism of LDL. Moment, Rosuvastatin inhibits hepatic blend of VLDL, which decreases the whole number of VLDL and LDL particles.


Dosage & Administration

Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mg

HoFH: Starting dose 20 mg/day.

Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age.

Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.

Rosuvastatin can be taken at any time of day, with or without food.



Exceptional sedate intelligent of Rosuvastatin are- Cyclosporine: Combination increments Rosuvastatin introduction. Rosuvastatin measurements ought to be constrained to 5 mg once daily. Gemfibrosil: Combination ought to be maintained a strategic distance from. On the off chance that utilized together, Rosuvastatin measurements ought to be constrained to 10 mg once daily. Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increments Rosuvastatin introduction. Rosuvastatin measurements ought to be to 10 mg once daily. Coumarin anticoagulants: Combination draws out universal normalized proportion (INR). Steady INR ought to be accomplished earlier to beginning Rosuvastatin. INR ought to be checked as often as possible until steady upon start or modification of Rosuvastatin therapy. Concomitant lipid-lowering treatments: Utilize with fibrates and niacin items may increment the hazard of skeletal muscle impacts.



If you have a known hypersensitivity to any of the product’s ingredients, you should avoid taking rosuvastatin.

Unexplained persistent elevations in hepatic transaminase levels are a sign of liver disease.

Women who are pregnant or may become pregnant

Mothers who are breastfeeding


Side Effect

Rosuvastatin is well tolerated by most people. Headache, myalgia, constipation, asthenia, abdominal pain, and nausea were the most common side effects linked to Rosuvastatin.


Pregnancy & Lactation

The safety of the drug in pregnant women has yet to be determined. Rosuvastatin is not known whether or not it is excreted in human milk.


Precautions & Warnings

Skeletal muscle impacts (e.g., myopathy and rhabdomyolysis): Dangers increment with utilize of 40 mg dosageprogressed age (>65 year), hypothyroidism, renal impedance and combination utilize with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs. Patients ought to be exhorted to instantly report unexplained muscle tormentdelicacy or shortcoming. Rosuvastatin can be ceased in the event that signs or side effects appear. Liver protein variations from the norm and observingTireless rises in hepatic transaminases can happen.


Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs, Statins


Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children’s reach.


Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.