Generic

Hydrocortisone Acetate

Indications

Hydrocortisone Acetate’s key therapeutic function is its anti-inflammatory action. It also possesses antimitotic and immunosuppressive properties. The use of hydrocortisone acetate is recommended in the following situations:
Dermatitis due to a primary irritant
Contact dermatitis is a type of allergic dermatitis that occurs when someone
Atopic eczema, infantile eczema, discoid eczema, stasis eczema
Seborrheic dermatitis (seborrheic dermatitis) is a type
Pruritus and lichen simplex ani
Flexural psoriasis is a type of psoriasis that affects the
Insect bites, small thermal burns, sunburn, and other skin irritations, itching, and rashes, for example.

Pharmacology

The cytosolic glucocorticoid receptor binds hydrocortisone. The newly formed receptor-ligand complex translocates into the cell nucleus after contacting the receptor, where it binds to numerous glucocorticoid response elements (GRE) in the promoter region of target genes. The DNA-bound receptor then interacts with basic transcription factors, causing certain target genes to express more. Lipocortins, phospholipase A2 inhibitory proteins that limit the formation of prostaglandins and leukotrienes by inhibiting arachidonic acid, are hypothesized to be involved in corticosteroids’ anti-inflammatory effects.Glucocorticoids cause the production of lipocortin-1 (annexin-1), which attaches to cell membranes and prevents the phospholipase A2 from interacting with its substrate arachidonic acid. Eicosanoid production is reduced as a result. The expression of cyclooxygenases (both COX-1 and COX-2) is likewise inhibited, amplifying the effect. In other words, the action of glucocorticoids inhibits the two primary products of inflammation, prostaglandins and leukotrienes.Glucocorticoids also cause lipocortin-1 to escape into the extracellular space, where it binds to leukocyte membrane receptors and inhibits a variety of inflammatory events, including epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst, and the release of inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines, and Corticosteroids also inhibit the immune system by lowering lymphatic system function, lowering immunoglobulin and complement concentrations, precipitating lymphocytopenia, and interfering with antigen-antibody interaction.

Dosage & Administration

Hydrocortisone Acetate should be applied in a small quantity to the affected area 2 or 3 times daily.

Contraindications

Bacterial, viral, and fungal infections are all possible. Ulcers on the skin. Intolerance to the preparation.

Side Effects

Although Hydrocortisone Acetate 1 percent cream is normally well tolerated, it should be discontinued if signs of hypersensitivity emerge.

Pregnancy & Lactation

In human pregnancy, there is insufficient proof of safety. Topical corticosteroids should not be used often during pregnancy, according to experts. During topical therapy, it is exceedingly improbable that sufficiently high blood levels of Hydrocortisone will be achieved to enter breast milk.

Precautions & Warnings

Long-term continuous topical medication in infants and children should be avoided if at all possible, as adrenal suppression can ensue. Prolonged use of corticosteroids on the face is not recommended, as it is with all corticosteroids.

Therapeutic Class

Other Topical corticosteroids

Storage Conditions

Store in a cool and dry place, away from light. Keep out of reach of children.

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.