Clovate-N 15 GM


Clovate-N 15 GM


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Indications of Clovate N 15 Ointment

This preparation is

  • Short courses treatment of recalcitrant eczemas.
  • Neurodermatitis.
  • Psoriasis (excluding widespread plaque psoriasis) where secondary bacterial infection or fungal infection is present, suspected, or likely to occur.
  • Other inflammatory conditions do not respond satisfactorily to less active steroids.

Pharmacology of Clovate N 15 Ointment

Clobetasol Propionate is a topical corticosteroid with a high potency. It works as an anti-inflammatory, anti-pruritic, and vasoconstrictor. It inhibits late-phase allergic reactions by exhibiting anti-inflammatory effects through different pathways. Mast cell density, chemotaxis, and eosinophil activation are all reduced. It also inhibits arachidonic acid metabolism and decreases cytokine production.

Dosage & Administration of Clovate N 15 Ointment

Adults: Apply sparingly to the affected area once or twice daily until improvement occurs. In very resistant lesions, especially where there is hyperkeratosis, the anti-inflammatory effect of this preparation can be enhanced (if necessary) by occluding the treatment area with polythene. Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient’s condition being reviewed.

Elderly: This preparation is suitable for use in the elderly. Caution should be exercised in cases where a decrease in renal function exists and significant systemic absorption of Neomycin Sulphate may occur.

Children: This preparation is suitable for use in children (2 years and over) at the same dose as adults. A possibility of increased absorption exists in very young children, thus this cream/ointment is not recommended for use in neonates and infants (younger than 2 years).

Interaction of Clovate N 15 Ointment

Neomycin sulfate can enhance and prolong the respiratory depression of neuromuscular blockers after significant systemic absorption. However, if used as recommended, the systemic exposure of neomycin sulfate is expected to be minimal, and drug interactions are unlikely to be significant. There are no reports of dangerous interactions with clobetasol propionate or nystatin.


The drug is contraindicated in rosacea, acne vulgaris, perioral dermatitis, primary skin viral infections (for example, herpes simplex, and chickenpox), and those who are allergic to the preparation.

Side Effects of Clovate N 15 Ointment

Like other topical corticosteroids, long-term large-scale use or large-area treatment may lead to adequate systemic absorption, resulting in the characteristics of hypercortisolism. If an occlusive dressing is used, this effect is more likely to occur in infants and children. Intensive and long-term treatment with highly active corticosteroid preparations can cause local atrophic changes in the skin, such as thinning, stretch marks, and superficial vasodilation, especially when the use of occlusive dressings or skin folds is affected. There are reports that topical steroids can cause pigmentation changes and hirsutism.

Pregnancy & Lactation

There is little data to prove the possible effects of topical neomycin on pregnancy and lactation. However, neomycin present in maternal blood can cross the placenta and, in theory, may pose risks of fetal toxicity, so its use during pregnancy and lactation is not recommended. The safety of clobetasol propionate in nursing mothers has not been established.

Precautions & Warnings

Long-term continuous topical treatment should be avoided as much as possible, especially in infants and children, because adrenal suppression is prone to occur even in the absence of occlusion. If applied to the eyelids, care must be taken to ensure that the preparation does not get into the eyes as it can cause glaucoma. If this medicine gets into your eyes, flush the affected eyes well with plenty of water.

Therapeutic Class

Clobetasol / Clobetasone & Combined Preparations

Storage Conditions

Store below 25°C temperature. Do not freeze. Keep out of reach of children.

Pharmaceutical Name of Clovate N 15 Ointment

ACI Limited

Generic of Clovate N 15 Ointment

Clobetasol Propionate + Neomycin Sulphate + Nystatin