Indications of Clotrim 10

Dermatomycoses due to candida, trichophyton, molds, and other fungi, skin diseases showing superinfections with these fungi e.g. inter digital mycoses, paronychia, candida vulvitis, balanitis, pityriasis versicolor, and erythrasma.

Pharmaceutical Name

ACME Laboratories Ltd.

Pharmacology

Clotrimazole works mainly by destroying the osmotic barrier in the fungal cell membrane. Clotrimazole inhibits the biosynthesis of ergosterol, which is an important component of fungal cell membranes. If the synthesis of ergosterol is completely or partially inhibited, the cell can no longer build a complete and functional cell membrane. Since ergosterol directly promotes the growth of fungal cells in a hormone-like manner, the rapid occurrence of the above events results in a dose-dependent inhibition of fungal growth.

Although it is recognized that the reduction of ergosterol due to the inhibition of lanosterol 14 demethylase (also known as CYP51) is the main reason for the antifungal properties of clotrimazole, the drug also shows other pharmacological effects. These include inhibition of sarcoplasmic reticulum Ca2 + ATPase, consumption of intracellular calcium, and blockade of calcium-dependent potassium channels and voltage-dependent calcium channels. The effects of clotrimazole on these targets explain other effects of the drug that differ from its antifungal activity.

Dosage & Administration of Clotrim 10

Afun® Cream should be thinly applied 2-3 times daily to the infected sites and rubbed in. On account of the excellent efficacy, a small amount of cream is usually sufficient for an area about the size of the palm. For the treatment to become a complete success, reliable and sufficiently long-time application of Afun® Cream is important. The duration of treatment varies; it depends among other factors on the extent and localization of the disease.

Contraindications

Hypersensitivity to Clotrimazole.

Side Effects of Clotrim 10

When applied topically, clotrimazole is well tolerated. When applied externally, no systemic effects were observed. In rare cases, local irritation or burning may occur, but these symptoms are not considered harmful.

Pregnancy & Lactation

It is recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician.

Precautions & Warnings

Before you use Afun Cream, discuss with your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information. Tell your doctor if you are allergic to any of the following substances: cetostearyl alcohol.

Therapeutic Class

Drugs for subcutaneous and mycoses, Topical Antifungal preparations

Storage Conditions

Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.

Generic Name of Clotrim 10

Clotrimazole.