Cloron 1MG


Cloron 1MG


Stock Status:

In Stock

  • *Upload Prescription

    • (max file size 80 MB)


Indications of Cloron 1 Tablet

It’s used to treat panic disorder, both with and without agoraphobia. Panic disorder is defined by the occurrence of sudden panic attacks, as well as the fear of having further attacks and anxiety about the implications or repercussions of the episodes.

It’s also used to treat Lennox-Gastaut Syndrome (petit mal type), akinetic seizures, and myoclonic seizures, either alone or in combination. Patients with absence seizures (petit mal) who have not responded to succinimides may benefit from it.

Clonazepam’s efficacy in long-term usage, defined as longer than 9 weeks, has not been well investigated in controlled clinical research. If a physician decides to use Clonazepam for a lengthy period of time, he or she should review the drug’s long-term effectiveness for the patient on a regular basis.


Pharmacology of Cloron 1 Tablet

Clonazepam has benzodiazepine-like pharmacological characteristics, such as anticonvulsive, sedative, muscle relaxing, and anxiolytic actions. Benzodiazepines’ central effects are mediated by an increase in GABAergic neurotransmission at inhibitory synapses. Positive allosteric modulation of the GABA receptor for the neurotransmitter is increased in the presence of benzodiazepines, resulting in greater effect of released GABA on the postsynaptic transmembrane chloride ion flow.

There is additional evidence of clonazepam’s impact on serotonin in animals. Clonazepam suppresses many types of paroxysmal activity, including spike and wave discharge in absence of seizures (petit mal), slow spike wave, generalized spike wave, spikes with temporal or other locations, as well as irregular spikes and waves, according to animal data and electroencephalographic investigations in humans. EEG abnormalities in general are repressed more frequently than abnormalities in specific areas. Clonazepam appears to be helpful in both widespread and localized epilepsies, according to these studies.


Dosage & Administration of Cloron 1 Tablet

Adults: For adults with seizure disorders, the first dosage should not exceed 1.5 mg/day, split into three doses. Dosage can be raised in 0.5 to 1 mg increments every 3 days until seizures are under control or adverse effects prevent further increases. Depending on the patient’s reaction, the maintenance dosage must be customized for each patient. The maximum daily dose that is suggested is 20 mg.

For individuals with panic disorder, the first dose is 0.25 mg split into two doses. After 3 days, most patients may get a 1 mg/day increase in their target dosage.

Pediatric Patients: The first dose for babies and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day, but not more than 0.05 mg/kg/day, given in divided doses.

Injection: Half a vial (0.5 mg) via gradual IV injection or IV infusion in infants and children.

Adults: 1 vial (1 mg) IV infusion or gradual IV injection. This dosage can be given as needed (1-4 mg are usually sufficient to reverse the status). In adults, the injection rate should not exceed 0.25-0.5 mg per minute (0.5-1.0 ml of the prepared solution) and the total dose should not exceed 10 mg.


Interaction of Cloron 1 Tablet

Phenytoin, carbamazepine, and phenobarbital pharmacokinetics do not appear to be affected by clonazepam. Clonazepam’s impact on the metabolism of other medications has not been studied.



It should not be used in individuals who have a history of benzodiazepine hypersensitivity, as well as those who have clinical or biochemical indications of severe liver damage. It can be utilized in individuals with open angle glaucoma who are on the right medication, but it’s not recommended for acute narrow angle glaucoma.


Side Effect of Cloron 1 Tablet

Clonazepam’s most common adverse effects include depression of the central nervous system (CNS). Drowsiness has been reported in around 50 percent of patients treated for seizures, with ataxia occurring in approximately 30 percent. These may improve with time in some situations; behavior issues have been reported in about 25% of individuals. Aphonia, coma, tremor, vertigo, disorientation, sadness, forgetfulness, hallucinations, hysteria, increased libido, sleeplessness, psychosis, and palpitations are some of the symptoms that might arise.


Pregnancy & Lactation

Pregnant womeni Safety of Clonazepam in pregnancy has not been established. Use of Clonazepam during pregnancy should be avoided, as administration of high doses or prolonqed use of low doses have been repofted to produce itregularities in the fetal heart, hypotonia and poor sucking and hypothermia in the neonate. Lactating mother: Clonazepam is excreted into the breast milk and can reach concentrations causing adverse effects and should therefore be avoided during breasueeding,


Precautions & Warnings

Clonazepam may increase the incidence or hasten the start of generalized tonic-clonic seizures in individuals who have multiple distinct forms of seizure disorders. This may necessitate the addition of or an increase in the dosage of anticonvulsants. The use of valproic acid and Clonazepam at the same time might cause absent status.


Therapeutic Class

Adjunct anti-epileptic drugs, Benzodiazepine hypnotics


Storage Conditions

Keep away from light and heat in a dry area. Keep out of children’s reach.


Pharmaceutical Name of Cloron 1 Tablet

Eskayef Pharmaceuticals Ltd


Generic of Cloron 1 Tablet