Indications of Clopid-As

In patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation Myocardial Infarction (NSTEMI)] and acute ST-segment elevation ACS [ST-elevation Myocardial Infarction (STEMI)], it is advised to reduce the rate of Myocardial Infarction (MI) and Stroke.

Recent MI, recent Stroke, or existing Peripheral Arterial Disease: It is advised to reduce the rate of MI and Stroke in patients with established peripheral arterial disease or a history of recent Myocardial Infarction (MI) or recent Stroke.

Pharmaceutical Name

Drug International Ltd

Pharmacology

Clopidogrel is a prodrug that is used to treat blood clots. The irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets suppresses platelet activation and aggregation. At 2 hours after single oral dosages, dose-dependent suppression of platelet aggregation can be noticed. On the first day, repeated 75 mg doses decrease ADP-induced platelet aggregation, and inhibition achieves a stable state between Days 3 and 7.

Aspirin prevents platelet aggregation by inhibiting platelet cyclooxygenase irreversibly, preventing the production of thromboxane A2, a potent inducer of platelet aggregation and vasoconstriction.

Dosage & Administration

The recommended oral dose is one tablet daily.

Interaction of Clopid-As

Oral anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), Metamizole, SSRIs, and CYP2C19 inhibitors all increase the risk of bleeding. Tonofovir, Valproic acid, Varicella vaccine, Acetazolamide, and Nicorandil all interact with it.

Contraindications

This combination should not be used if you have any of the following conditions: Hypersensitivity to the medicine or any of the product’s components. Peptic ulcer or cerebral hemorrhage are examples of active pathological bleeding.

Side Effects of Clopid-As

This combination is generally well tolerated.

Pregnancy & Lactation

In pregnant women, there are no sufficient and well-controlled trials. It should only be taken if absolutely necessary throughout the first and second trimesters of pregnancy. During the third trimester of pregnancy, it is not recommended. Clopidogrel is not known to be excreted in human breast milk, however it is known to be excreted in human milk. During breast-feeding, this drug should be avoided.

Precautions & Warnings

This combination may cause bleeding to take longer.

TTP (thrombotic thrombocytopenic purpura) has been documented seldom as a side effect of this combination.

Reye’s syndrome is a condition that affects people. Individuals with chicken pox, influenza, or flu symptoms may develop Reye’s syndrome. Patients receiving this combination or who have a history of hypersensitivity to other thienopyridines have suffered rash, angioedema, or hematologic reactions.

Therapeutic Class

Anti-platelet drugs

Storage Conditions

Keep in a cool & dry place (below 30o C), protected from light & moisture. Keep out of the reach of children.

Generic Name of Clopid-As

Clopidogrel + Aspirin