Indications of Ciprox 500 Tablet

Ciprofloxacin is used to treat Respiratory Tract Infections, Urinary Tract Infections, Pelvic Inflammatory Diseases, Infectious Diarrhea (Shigella dysentery, Vibrio cholera), Typhoid Fever, Intra-abdominal Infections, Prostatitis, Skin and Soft Tissue Infections, Bone and Joint Infections, Gonorrhea, Neutropenic individuals with fever caused by a bacterial infection, Meningitis, and surgical prophylaxis.

Pharmacology of Ciprox 500 Tablet

Ciprofloxacin is a fluoroquinolone antibiotic. It is bactericidal to a wide variety of gram-positive and gram-negative species. It prevents bacterial DNA synthesis by attaching to the bacterial enzymes DNA gyrase and topoisomerase IV, which are in charge of DNA supercoiling.

Dosage of Ciprox 500 Tablet

Tablet: Adult:

• Respiratory Tract Infections: 500 to 750 mg twice daily (7 to 14 days)
• Urinary tract infections: 250 to 750 mg twice daily (3 to 10 days)
• Pelvic Inflammatory Diseases: 500 to 750 mg twice daily (14 days)
• Infectious Diarrhea (Shigella dysentery, Vibrio cholera): 500 mg twice daily (1 to 5 days)
• Typhoid fever: 500 mg twice daily (7 days)
• Intra-abdominal infections: 500 to 750 mg twice daily (5 to 14 days)
• Prostatitis: 500 to 750 mg twice daily (2 to 6 weeks)
• Skin and Soft Tissue Infections: 500 to 750 mg twice daily (7 to 14 days)
• Bone and Joint Infections: 500 to 750 mg twice daily (max. 3 months)
• Gonorrhea: 500 mg as a single dose
• Neutropenic patients with fever due to bacterial infection: 500 to 750 mg twice daily co-administered with appropriate antibacterials.
• Meningitis: 500 mg as a single dose.
• Surgical prophylaxis: 500 mg as a single dose, 60 minutes before the procedure.

Suspension: Pediatric: 10-20 mg/kg (max. 750 mg) twice daily (10 to 21 days). The duration of therapy depends on the type and severity of the infection.

Extended-release tablet: In uncomplicated urinary tract infections (acute cystitis), the recommended dose of the extended-release tablet is 1000 mg tablet once daily for three days.

For IV infusion:

• Urinary Tract Infection: Mild to Moderate: 200 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 12 hourly for 7-14 days
• Lower Respiratory Tract Infection: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days
• Nosocomial Pneumonia: Mild/Moderate/Severe: 400 mg 8 hourly for 10-14 days
• Skin and Skin Structure: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days
• Bone and Joint Infection: Mild to Moderate: 400 mg 12 hourly for more than 4-6 weeks; Severe/Complicated: 400 mg 8 hourly for more than 4-6weeks
• Intraabdominal (Acute abdomen): Complicated: 400 mg 12 hourly for 7-14 days
• Acute Sinusitis: Mild/Moderate: 400 mg 12 hourly for 10 days
• Chronic Bacterial Prostatitis: Mild/Moderate: 400 mg 12 hourly for 28 Days.

Administration of Ciprox 500 Tablet

Instruction for the use of Ciprofloxacin IV infusion-

• Check the bag for minute leaks by squeezing the inner bag firmly. If leaks are found, or if the seal is not intact, discard the solution.
• Do not use it if the solution is cloudy or a precipitate is present.
• Do not use flexible bags in series connections.
• Close flow control clamp of administration set.
• Remove the cover from the port at the bottom of the bag.
• Insert the piercing pin of administration set into the port with a twisting motion until the pin is firmly seated.
• Suspend the bag from the hanger.
• Squeeze and release the drip chamber to establish proper fluid level in the chamber during infusion of Ciprofloxacin IV infusion.
• Open the flow control clamp to expel air from the set. Close clamp.
• Regulate rate of administration with flow control clamp

Duration of treatment: The duration of treatment depends upon the severity of the infection, clinical response, and bacteriological findings. For acute infections, the usual treatment period is 5 to 10 days. Generally, treatment should be continued for 3 days after the signs and symptoms of the infection have disappeared.

Interaction of Ciprox 500 Tablet

Ciprofloxacin should not be taken concurrently with antacids or sucralfate containing magnesium or aluminum, or with other products containing calcium, iron, or zinc. These medications should be given two hours after or six hours before Ciprofloxacin. Ciprofloxacin should not be taken in conjunction with milk or other dairy products since absorption may be considerably decreased. Although dietary calcium is consumed as part of a meal, it has no effect on Ciprofloxacin absorption.

Contraindications

It is not recommended for individuals who have a history of hypersensitivity to Ciprofloxacin or other quinolones.

Side Effects of Ciprox 500 Tablet

Nausea and other gastrointestinal problems, headache, dizziness, joint pain, and skin rashes are all possible side effects.

Pregnancy & Lactation

In pregnant women, there are no appropriate and well-controlled trials. Ciprofloxacin should only be taken during pregnancy if the possible benefit outweighs the danger to the fetus and mother. Ciprofloxacin is a drug that is excreted in human milk. Ciprofloxacin should not be taken during breastfeeding due to the risk of articular injury.

Precautions & Warnings

Patients using Ciprofloxacin should be advised to drink plenty of water. It should be taken with caution in individuals who have suspected or known CNS diseases such as epilepsy or other conditions that predispose them to seizures and convulsions. In patients with known QT prolongation or hypokalemia, avoid it.

Therapeutic Class

4-Quinolone preparations, Anti-diarrhoeal Antimicrobial drugs

Storage Conditions

Maintain a temperature of less than 30°C and keep it away from light and moisture. Keep out of children’s reach.

Pharmaceutical Name of Ciprox 500 Tablet

Opsonin Pharma Limited

Generic of Ciprox 500 Tablet

Ciprofloxacin