Description
Indications of Centoxin 60 ml
Digoxin is prescribed for the following conditions:
- Failure of the heart.
- Atrial fibrillation is accompanied with an unregulated ventricular rate.
- Acute failure of the left ventricle.
- Chronic left ventricular failure and congestive heart failure, particularly when caused by hypertensive valvular disease (particularly mitral valve disease) or ischemic heart disease.
Pharmaceutical Name of Centoxin 60 ml
Opsonin Pharma Ltd.
Pharmacology
Digoxin is a cardiac glycoside that is used to treat a variety of heart conditions, including atrial fibrillation and heart failure. Digoxin’s main effects include an increase in myocardial contraction force (positive inotropic activity) and a decrease in cardiac conductivity, notably in conduction through the atrioventricular node. Digoxin has both direct and indirect effects on vascular smooth muscle, with the latter being mediated largely via the autonomic nervous system and, in particular, an increase in vagal activity.
Dosage & Administration
By oral administration:
- Rapid digitalization: 1-1.5 mg in divided doses over 24 hours
- Less urgent digitalization: 250-500 micrograms daily (higher dose may be divided)
- Maintenance: 62.5-500 micrograms daily (higher dose may be divided) according to renal function and in atrial fibrillation on heart rate response.
- Usual range: 125-250 micrograms daily (lower dose may be divided) according to renal function and in atrial fibrillation on heart rate response.
- Usual range: 125-250 micrograms daily (lower dose may be appropriate for the elderly).
Interaction of Centoxin 60 ml
Diuretics that deplete potassium enhance the effects of digitalis. Calcium, especially when given quickly through intravenous methods, can cause severe arrhythmia in digitalized individuals. Digoxin serum levels are raised by quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, spironolactone, erythromycin, clarithromycin (and potentially other macrolide antibiotics), and tetracycline. Aside from antacids, kaolin-pectin, sulfasalazine, neomycin, penicillamine, colestipol, metoclopramide, and rifampin may inhibit digoxin absorption in the intestine, resulting in low blood levels of the medication.
Contraindications
- Ventricular fibrillation.
- Hypersensitivity to digoxin or other digitalis preparation.
Side Effects of Centoxin 60 ml
Anorexia, nausea, vomiting, diarrhea, abdominal pain, visual disturbances, headache, fatigue, drowsiness, confusion, delirium, hallucination, depression, arrhythmia, heart block, intestinal ischemia, gynecomastia with long-term use, and thrombocytopenia have all been reported as side effects of excessive dosage. Digoxin is safe to take throughout pregnancy.
Pregnancy & Lactation
Digoxin is excreted in breast milk at concentrations lower than those found in plasma, posing no risk to the breastfed child.
Precautions & Warnings
Cardiovascular dysrhythmias, hypokalaemia, hypertension, IHD, hypercalcemia, hypomagnesemia, electro conversion, chronic cor pulmonale, aortic valve disease, acute myocarditis, congestive cardiomyopathies, constrictive pericarditis, heart block, elderly, renal impairment, thyroid function abnormalities; pregnancy Only individuals who have not received cardiac glycosides in the previous two weeks can be administered IV digoxin.
Therapeutic Class
Store in a cool, dry location. Keep out of children’s reach.
Generic of Centoxin 60 ml