Centoxin 0.25 MG

102510063200201

Centoxin 0.25 MG

1.09৳ 

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In Stock

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Description

Indications of Centoxin 0.25

Digoxin is prescribed for the following conditions:

  • Failure of the heart.
  • Atrial fibrillation is accompanied by an unregulated ventricular rate.
  • Acute failure of the left ventricle.
  • Chronic left ventricular failure and congestive heart failure, particularly when caused by hypertensive valvular disease (particularly mitral valve disease) or ischemic heart disease.

 

Pharmaceutical Name of Centoxin 0.25

Opsonin Pharma Ltd.

 

Pharmacology

Digoxin is a cardiac glycoside that is used to treat a variety of heart conditions, including atrial fibrillation and heart failure. Digoxin’s main effects include an increase in myocardial contraction force (positive inotropic activity) and a decrease in cardiac conductivity, notably in conduction through the atrioventricular node. Digoxin has both direct and indirect effects on vascular smooth muscle, with the latter being mediated largely via the autonomic nervous system and, in particular, an increase in vagal activity.

 

Dosage & Administration

By oral administration:

  • Rapid digitalization: 1-1.5 mg in divided doses over 24 hours
  • Less urgent digitalization: 250-500 micrograms daily (higher dose may be divided)
  • Maintenance: 62.5-500 micrograms daily (higher dose may be divided) according to renal function and in atrial fibrillation on heart rate response.
  • Usual range: 125-250 micrograms daily (lower dose may be divided) according to renal function and in atrial fibrillation on heart rate response.
  • Usual range: 125-250 micrograms daily (a lower dose may be appropriate for the elderly).

 

Interaction of Centoxin 0.25

Diuretics that deplete potassium enhance the effects of digitalis. Calcium, especially when given quickly through the intravenous method, can cause severe arrhythmia in digitalized individuals. Digoxin serum levels are raised by quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, spironolactone, erythromycin, clarithromycin (and potentially other macrolide antibiotics), and tetracycline. Aside from antacids, kaolin-pectin, sulfasalazine, neomycin, penicillamine, colestipol, metoclopramide, and rifampin may inhibit digoxin absorption in the intestine, resulting in low blood levels of the medication.

 

Contraindications

  • Ventricular fibrillation.
  • Hypersensitivity to digoxin or other digitalis preparation.

 

Side Effects of Centoxin 0.25

Anorexia, nausea, vomiting, diarrhoea, abdominal pain, visual disturbances, headache, fatigue, drowsiness, confusion, delirium, hallucination, depression, arrhythmia, heart block, intestinal ischaemia, gynecomastia with long-term use, and thrombocytopenia have all been reported as side effects of excessive dosage. Digoxin is safe to take throughout pregnancy.

 

Pregnancy & Lactation

Digoxin is excreted in breast milk at concentrations lower than those found in plasma, posing no risk to the breastfed child.

 

Precautions & Warnings

Cardiovascular dysrhythmias, hypokalaemia, hypertension, IHD, hypercalcaemia, hypomagnesaemia, electro conversion, chronic cor pulmonale, aortic valve disease, acute myocarditis, congestive cardiomyopathies, constrictive pericarditis, heart block, elderly, renal impairment, thyroid function abnormalities; pregnancy Only individuals who have not received cardiac glycosides in the previous two weeks can be administered IV digoxin.

 

Therapeutic Class

Positive Inotropic drugs

 

Storage Conditions

Store in a cool, dry location. Keep out of children’s reach.

 

Generic of Centoxin 0.25

Digoxin