Indications

Bisoprolol is indicated-

• Hypertension
• Angina
• Moderate to severe heart failure.

Pharmacology

Bisoprolol hemifumarate is the most selective ß1 blocker. It displays the highest level of affinity for the ß1 receptor than any other beta-blocker available up to now. Selectively blocks ß1 adrenergic receptors in the heart and vascular smooth muscle and reduces heart rate and cardiac output resulting in a decrease in arterial hypertension. Lipid metabolism can be adversely affected by ß-blockers, in patients with non-ß1 selective ß1-blocker, but Bisoprolol does not cause any change in the cholesterol fraction including the cardioprotective HDL-cholesterol, in long-term therapy.

Administration & Dosage

Hypertension: The dose of Bisoprolol must be individualized to the needs of the patient. The usual starting dose is 5 mg once daily. In some patients, 2.5 mg may be an appropriate starting dose. If the antihypertensive effect of 5 mg is inadequate, the dose may be increased to 10 mg and then, if necessary, to 20 mg once daily.

Angina: Usually 10 mg once daily (5 mg may be adequate in some patients) max 20 mg daily.

Heart Failure: Initially 1.25 mg once daily (in the morning) for 1 week then, if well tolerated, increased to 2.5 mg once daily for 1 week, then 3.75 mg once daily for 1 week, then 5 mg once daily for 4 weeks, then- 7.5 mg once daily for 4 weeks, then 10 mg once daily maximum 10 mg daily.

Interaction

Bisoprolol should not be combined with other ß-blocking agents.

Contraindications

In patients with cardiogenic shock, overt heart failure, second or third-degree A-V block, right ventricular failure secondary to pulmonary hypertension, and sinus bradycardia.

Side Effects of Bisoloc 5 Tablet

Gastrointestinal disturbances, bradycardia, hypotension, headache, fatigue, sleep disturbances, dizziness, vertigo, thrombocytopenia, visual disturbances, and alopecia may occur.

Pregnancy & Lactation

The safety of bisoprolol during pregnancy has not been established. No data is available for lactation.

Precautions & Warnings

Monitoring of renal, hepatic, and hematopoietic function should be performed at regular intervals during long-term treatment with bisoprolol.

Therapeutic Class

Anti-adrenergic agents (Beta-blockers), Beta-adrenoceptor blocking drugs, Beta-blockers

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children’s reach.

Pharmaceutical Name