Indications

Bisocor 2.5 is indicated-

• Hypertension
• Angina
• Moderate to severe heart failure

Pharmacology

Bisoprolol hemifumarate is the most selective ß1 blocker. It has the highest affinity for ß1 receptors compared to any other beta blockers available to date. It selectively blocks ß1 adrenergic receptors in the heart and vascular smooth muscles, reducing heart rate and cardiac output, thereby reducing arterial hypertension. The lipid metabolism of patients using non-selective β-1 blockers may be adversely affected by β-blockers, but in long-term treatment, bisoprolol will not produce any changes in cholesterol scores, including the heart Protective HDL cholesterol.

Dosage & Administration

Hypertension: The dosage of bisoprolol should be individualized according to the needs of the patient. The usual starting dose is 5 mg once a day. In some patients, 2.5 mg may be a suitable starting dose. If the antihypertensive effect of 5 mg is insufficient, the dose can be increased to 10 mg, if necessary, to 20 mg, once a day.

Angina: generally 10 mg per day (5 mg may be sufficient for some patients), up to 20 mg per day.

Heart failure: Initially 1.25 mg once daily (in the morning) for 1 week, then, if well tolerated, increase to 2.5 mg once daily for 1 week, then to 3.75 mg per day for 1 week, then 5 mg a day for 4 weeks, then 7.5 mg a day mg once for 4 weeks, then 10 mg once a day, up to 10 mg a day.

Interaction

Bisocor 2.5 should not be combined with other beta-blockers.

Contraindications

Patients with cardiogenic shock, evident heart failure, second or third-degree atrioventricular block, and right ventricular failure secondary to pulmonary hypertension and sinus bradycardia.

Side Effects

There may be gastrointestinal disorders, bradycardia, hypotension, headache, fatigue, sleep disturbance, dizziness, dizziness, thrombocytopenia, visual disturbance, and hair loss.

Pregnancy & Lactation

The safety of bisoprolol during pregnancy has not been established. There are no data on breastfeeding.

Precautions & Warnings

During long-term treatment with bisoprolol, kidney, liver, and hematopoietic functions should be monitored regularly.

Therapeutic Class

Anti adrenergic agents (Beta-blockers), Beta-adrenoceptor blocking drugs, Beta-blockers

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Pharmaceutical Name

Square Pharmaceuticals Ltd

Generic

Bisoprolol Hemifumarate