Indications

Bilastine is used to treating allergic rhino-conjunctivitis (seasonal and perennial) and urticaria symptomatically.

Pharmacology

Bilastine may be a non-sedating, long-acting histamine adversary with particular fringe H 1 receptor opponent liking and no fondness for muscarinic receptors. Bilastine represses histamine-induced wheal and flare skin responses for 24 hours taking after single dosages.

Dosage & Administration

Adults & adolescents (12 years of age and over): 20 mg tablet once daily for symptomatic relief of allergic rhinitis, urticaria, and allergic rhinoconjunctivitis. The maximum recommended daily dose is 20 mg Bilastine (1 tablet) and should not be exceeded. If a dose is missed, the next scheduled dose should be taken. An extra dose should not be taken. 20 mg Bilastine tablet (1 tablet) once daily should be swallowed with water on an empty stomach to achieve optimal exposure to Bilastine.

Children between 6 to 11 years: 10 mg mouth dissolving tablet for the symptomatic relief of allergic rhinitis, allergic rhinoconjunctivitis, and urticaria. The Mouth dissolving tablet is for oral use only. It should be placed in the mouth. It will disperse rapidly in saliva and can be easily swallowed. Alternatively, the mouth-dissolving tablet can be dispersed in a teaspoon of water before being swallowed by the children. The maximum recommended daily dose for children between 6 to 11 years is 10 mg Bilastine mouth-dissolving tablet (1 tablet) and should not be exceeded. If a dose is missed, the next scheduled dose should be taken. An extra dose should not be taken.

Children between 2 to 11 years: 4 ml once daily.

Interaction

Concomitant admissions of Bilastine and Ketoconazole or Erythromycin or Diltiazem expanded C max of Bilastine. The psychomotor execution after concomitant admissions of liquor and Bilastine was comparable to that watched after admissions of liquor and fake treatment. Concomitant admissions of Bilastine and Lorazepam 3 mg for 8 days did not potentiate the depressant CNS impacts of Lorazepam.

Contraindications

Bilastine is not recommended for people who are hypersensitive to the active ingredient or any of the tablet’s excipients.

Side Effects

There is no or limited amount of data on the use of Bilastine in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity, parturition, or postnatal development. As a precautionary measure, it is preferable to avoid the use of Bilastine during pregnancy. The excretion of Bilastine in milk has not been studied in humans. A decision must be made taking into account the benefit of breastfeeding for the child and the benefit of Bilastine therapy for the mother.

Pregnancy & Lactation

There is no constrained sum of information from the utilization of Bilastine in pregnant ladies. Creature considers don’t show coordinate or circuitous hurtful impacts with regard to regenerative poisonous quality, parturition, or postnatal advancement. As a prudent degree, it is ideal to dodge the utilization of Bilastine during pregnancy. The excretion of Bilastine in the drain has not been examined in people. A choice must be made taking into consideration the advantage of breastfeeding for the child and the good thing about Bilastine treatment for the mother.

Precautions & Warnings

Co-administration of Bilastine and P-glycoprotein inhibitors (e.g. Ketoconazole, Erythromycin, Cyclosporine, Ritonavir, or Diltiazem) ought to be dodged in patients with direct or extreme renal disability.

Therapeutic Class

Non-sedating antihistamines.

Storage Conditions

Keep below 30°C temperature, protected from light and moisture. Keep out of reach of children.

Generic Name

Bilastine

Pharmaceuticals name

Popular Pharmaceuticals Ltd.