Indications

This topical preparation is indicated for the topical treatment of inflammatory dermal infections like-

• Tinea pedis
• Tinea cruris
• Tinea corporis etc.

Pharmacology of Betson-CL Ointment

Clotrimazole is a broad-spectrum antifungal drug that is used to treat infections caused by pathogenic dermatophytes, yeasts, and Malassezia furfur. Inhibition of the formation of ergosterol, a key sterol in the fungal cell membrane, is the mechanism of action. As a result, the cell membrane becomes unstable, and the fungus eventually dies. Betamethasone dipropionate is an anti-inflammatory, anti-pruritic, and vasoconstrictive corticosteroid. However, the precise mechanism of action of corticosteroids remains unknown.

Dosage & Administration of Betson-CL Ointment

Sufficient topical preparation should be applied onto the affected and surrounding skin areas twice a day, in the morning and evening, for 2 weeks in tinea cruris and tinea corporis and for 4 weeks in tinea pedis. The use of this cream for longer than four weeks is not recommended.

The safety and effectiveness of the preparation have not been established in children below the age of 12 years.

Contraindications

Patients who are allergic to any of the ingredients in this topical solution, as well as other corticosteroids or imidazoles, should avoid using it. If irritation or sensitization occurs as a result of using the cream, treatment should be stopped and proper therapy started. Facial rosacea, acne vulgaris, perioral dermatitis, perianal and vaginal pruritus, napkin eruptions, and bacterial or viral infections are all contraindications to using the cream. Topical corticosteroids can cause reversible inhibition of the hypothalamic-pituitary-adrenal (HPA) axis when absorbed systemically. If HPA axis suppression is observed, the medicine should be discontinued or the frequency of application reduced.

Side Effects of Betson-CL Ointment

Adverse reactions reported for the preparation in clinical trials were paresthesia in 1.9% of patients, rash, edema, and secondary infection, each in less than 1% of patients. Other adverse reactions reported with the preparation were burning and dry skin in 1.6% of patients and stinging in less than 1% of patients

Pregnancy & Lactation

In pregnancy, there is insufficient proof of safety. Clotrimazole is not teratogenic in animals, although it is foetotoxic at high dosages. Corticosteroids used topically to pregnant animals can cause fetal development problems. As a result, the cream should only be used during pregnancy if the benefit outweighs the danger to the fetus, and it should not be used in large amounts or for lengthy periods of time. Because it is unknown whether the preparation’s components are excreted in human milk, caution should be used when treating nursing women.

Therapeutic Class

Betamethasone & Combined preparations

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children’s reach.

Pharmaceutical Name of Betson-CL Ointment

Opsonin Pharma Ltd

Generic of Betson-CL Ointment

Betamethasone + Clotrimazole