Generic

Vitamin B complex

Indications

In physiologically demanding settings, vitamin B complex is recommended for preventative or therapeutic nutritional supplementation. Glossitis, stomatitis, cheilosis, and beriberi are examples of conditions that cause depletion or impaired absorption or bioavailability of critical B vitamins. In physiologically demanding settings, vitamin B complex is recommended for preventative or therapeutic nutritional supplementation. Glossitis, stomatitis, cheilosis, and beriberi are examples of conditions that cause depletion or impaired absorption or bioavailability of critical B vitamins.

Pharmacology

The most significant elements of the vitamin B group are present in pure form and in therapeutically adjusted amounts in the vitamin B complex. Vitamin B complex contains members of the vitamin B group, which are components of enzyme systems that regulate various stages of carbohydrate, lipid, and protein metabolism, with each component serving a unique biological function. Glossitis, stomatitis, cheilosis, polyneuritis, beriberi, pellagra, and corneal vascularization are all symptoms of B vitamin deficiency.

Dosage & Administration

Film-coated tablet: The usual initial dose is 40 to 80 mg daily. The dose can be increased up to 320 mg daily in divided doses when needed. The drug should be taken before meals. For children, Gliclazide is not used because it is contraindicated in juvenile-onset diabetes.

Modified release preparation: The usual daily dosage for Gliclazide 30 mg is 1 to 4 tablets & Gliclazide 60 mg is 1 to 2 tablets per day as a single dose. It is recommended that the drug should be taken at breakfast time. It is preferable to take this drug before breakfast in order to avoid or to minimize the possible onset of digestive disorders.

Interaction

Aspirin, NSAIDs, Phenylbutazone, Clofibrate, Sulfonamide, Cimetidine, Imidazole antifungal medications, and Monoamine Oxidase inhibitors may exacerbate Gliclazide’s hypoglycaemic effects. Rifampin, Barbiturates, Phenytoin, Thiazide diuretics, Diazoxide, Glucocorticoids, Estrogens, Sympathomimetic medications, and Alcohol may diminish the hypoglycaemic impact of Gliclazide.

Contraindications

Gliclazide should not be used in the following conditions: Juvenile-onset (type-1) diabetes Diabetes with Ketosis. Diabetic individuals having surgery, recovering from a serious accident, or in the midst of an infection. Patients who are hypersensitive to the sulfonylurea medication class. Pregnant ladies and mothers who are breast-feedingInsufficiency of the liver.

Side Effects

There may be hypoglycemia in concurrent conditions such as hepatic and renal disease, malnutrition, and alcohol intoxication. Sometimes headache, gastrointestinal upsets, nausea, dizziness, and skin reactions including rash, pruritus, and erythema may occur.

Pregnancy & Lactation

Gliclazide is contraindicated in pregnant women. It should not be used in breastfeeding mothers.

Precautions & Warnings

Gliclazide should be used carefully in patients with hepatic impairment. If there is a definite hepatic disease then gliclazide should not be used. Gliclazide can be used safely in patients with renal insufficiency as it is extensively metabolized. Gliclazide has fewer sudden hypoglycaemic episodes than another sulfonylurea group of drugs

Therapeutic Class

Sulfonylureas

Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children’s reach.

Pharmaceutical Name

Renata Limited