Indications

Vitamin B1, B6, and B12 are used to treat vitamin B1, B6, and B12 deficiency syndromes. It is also used as a supportive treatment for non-inflammatory diseases of inflammation and nerves.

•  Diabetic neuralgia
•  Peripheral neuralgia
•  Low back pain
•  Muscle pain
•  Optic neuritis
•  Sciatica
•  Facial neuralgia
•  Intercostal neuralgia
•  Back pain.

Pharmacology

Vitamin B1 converts carbohydrates, fatty acids, and amino acids into energy, promotes healthy nerves, improves mood, and strengthens the heart. Vitamin B6 forms red blood cells, helps cells make protein, produces neurotransmitters like serotonin and releases stored forms of energy, helps prevent CV disease and stroke, helps improve symptoms of depression, and reduces insomnia. Vitamin B12 is needed for cell replication and is important for the production of red blood cells, prevents anemia, helps prevent depression, relieves nerve pain, numbness, and tingling, and reduces the risk of heart disease.

Vitamin components are well absorbed orally. It is widely distributed in most tissues and is found in breast milk. In cells, thiamine is mainly present as diphosphate. Thiamine is not stored to appreciable levels in the body, and amounts in excess of the body’s requirements are excreted in the urine as unchanged thiamine or as a metabolite. Pyridoxine, pyridoxal, and pyridoxamine are readily absorbed by GIT after oral administration and converted to the active forms of pyridoxal phosphate and pyridoxamine phosphate. They are stored mainly in the liver, where there is oxidation to pyridoxic acid and other inactive metabolites, which are excreted in the urine. As the dose is increased, a correspondingly larger amount is excreted unchanged in the urine.

Dosage & Administration

Tablet: 1-3 Tablets per day or as advised by the physician.

Injection:

In severe (acute) cases: 1 injection daily until the acute symptoms subside or taken as advised by the physician.

In mild cases: 1 injection 2-3 times per week. Ampoules are preferably injected intramuscularly.

Use in children: There is no information on the use of this drug in children.

Contraindications

Vitamin B1, Vitamin B6, and Vitamin B12 are contraindicated in patients on levodopa therapy, and in patients with hypersensitivity to any of the ingredients of the preparation.

Side Effects

Generally well tolerated but allergic reactions may be observed in a few cases.

Pregnancy

Oral tablet form is recommended but due to the presence of benzyl alcohol, injection is not recommended during pregnancy & lactation.

Precautions

Patients with subacute spinal cord degeneration should not use cyanocobalamin. Cyanocobalamin is not a suitable form of vitamin B12 and is used to treat optic neuropathy associated with elevated plasma levels of cyanocobalamin.

Therapeutic Class

Specific combined vitamin preparations

Storage Conditions

Keep out of reach of children. Store in a cool (below 25°C temperature) and dry place, protected from light.

Generic

Vitamin B1, B6 & B12

Pharmaceutical Name

Popular Pharmaceuticals Ltd.